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FBXO45 F-box protein 45 [ Homo sapiens (human) ]

Gene ID: 200933, updated on 1-Jun-2020

Summary

Official Symbol
FBXO45provided by HGNC
Official Full Name
F-box protein 45provided by HGNC
Primary source
HGNC:HGNC:29148
See related
Ensembl:ENSG00000174013 MIM:609112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbx45
Summary
Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]
Expression
Ubiquitous expression in brain (RPKM 6.3), testis (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See FBXO45 in Genome Data Viewer
Location:
3q29
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (196568660..196589059)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196295725..196315930)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374307 Neighboring gene single-pass membrane protein with coiled-coil domains 1 Neighboring gene ribosomal protein S29 pseudogene 3 Neighboring gene WD repeat domain 53 Neighboring gene long intergenic non-protein coding RNA 1063 Neighboring gene negative regulator of reactive oxygen species

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterior commissure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cerebral cortex radially oriented cell migration IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex tangential migration IEA
Inferred from Electronic Annotation
more info
 
corticospinal tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse assembly involved in innervation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
F-box/SPRY domain-containing protein 1
Names
F-box only protein 45
hFbxo45

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105573.2NP_001099043.1  F-box/SPRY domain-containing protein 1

    See identical proteins and their annotated locations for NP_001099043.1

    Status: VALIDATED

    Source sequence(s)
    AC092933, BE047625, BE778263, CA445163, DB636510
    Consensus CDS
    CCDS46985.1
    UniProtKB/Swiss-Prot
    P0C2W1
    Related
    ENSP00000310332.6, ENST00000311630.7
    Conserved Domains (2) summary
    cd12907
    Location:112286
    SPRY_Fbox; SPRY domain in the F-box family Fbxo45
    pfam12937
    Location:3883
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    196568660..196589059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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