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SLC51A solute carrier family 51 alpha subunit [ Homo sapiens (human) ]

Gene ID: 200931, updated on 3-Sep-2017
Official Symbol
SLC51Aprovided by HGNC
Official Full Name
solute carrier family 51 alpha subunitprovided by HGNC
Primary source
HGNC:HGNC:29955
See related
Ensembl:ENSG00000163959 MIM:612084; Vega:OTTHUMG00000155684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSTA; OSTalpha
Orthologs
Location:
3q29
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (196216512..196233430)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195943383..195960301)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374303 Neighboring gene zinc finger DHHC-type containing 19 Neighboring gene uncharacterized LOC105374304 Neighboring gene phosphate cytidylyltransferase 1, choline, alpha Neighboring gene Tctex1 domain containing 2 Neighboring gene TM4SF19-TCTEX1D2 readthrough (NMD candidate) Neighboring gene uncharacterized LOC107986031

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of organic solute transporter alpha (OSTalpha) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Drug Induction of Bile Acid Pathway, organism-specific biosystem (from WikiPathways)
    Drug Induction of Bile Acid Pathway, organism-specific biosystem
    Drug Induction of Bile Acid Pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC39807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
 
bile acid and bile salt transport ISS
Inferred from Sequence or Structural Similarity
more info
 
transport IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
organic solute transporter subunit alpha
Names
OST-alpha
organic solute transporter alpha
organic solute transporter, alpha subunit
solute carrier family 51 subunit alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152672.5NP_689885.4  organic solute transporter subunit alpha

    See identical proteins and their annotated locations for NP_689885.4

    Status: VALIDATED

    Source sequence(s)
    AC069257
    Consensus CDS
    CCDS3314.1
    UniProtKB/Swiss-Prot
    Q86UW1
    Related
    ENSP00000296327.5, OTTHUMP00000208487, ENST00000296327.9, OTTHUMT00000341253
    Conserved Domains (1) summary
    pfam03619
    Location:53321
    Solute_trans_a; Organic solute transporter Ostalpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

    Range
    196216512..196233430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    195914213..195931131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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