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DHFR2 dihydrofolate reductase 2 [ Homo sapiens (human) ]

Gene ID: 200895, updated on 23-Nov-2021

Summary

Official Symbol
DHFR2provided by HGNC
Official Full Name
dihydrofolate reductase 2provided by HGNC
Primary source
HGNC:HGNC:27309
See related
Ensembl:ENSG00000178700 MIM:616588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHFRL1; DHFRP4
Expression
Ubiquitous expression in ovary (RPKM 4.0), endometrium (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

See DHFR2 in Genome Data Viewer
Location:
3q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (94057922..94063389, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (93776766..93781760, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 13B Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 7 Neighboring gene syntaxin 19 Neighboring gene NOP2/Sun RNA methyltransferase 3 Neighboring gene RBBP4 pseudogene 2 Neighboring gene VISTA enhancer hs1462

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dihydrofolate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dihydrofolate reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables folate reductase activity TAS
Traceable Author Statement
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in dihydrofolate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in folic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in folic acid metabolic process TAS
Traceable Author Statement
more info
 
involved_in glycine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tetrahydrofolate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tetrahydrofolate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thymidine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrial inner membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dihydrofolate reductase 2, mitochondrial
Names
dihydrofolate reductase like 1
dihydrofolate reductase pseudogene 4
dihydrofolate reductase, mitochondrial
dihydrofolate reductase-like protein 1
NP_001182572.1
NP_789785.1
XP_011510839.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195643.2NP_001182572.1  dihydrofolate reductase 2, mitochondrial

    See identical proteins and their annotated locations for NP_001182572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC130896, AW104373
    Consensus CDS
    CCDS2926.1
    UniProtKB/Swiss-Prot
    Q86XF0
    Related
    ENSP00000377768.2, ENST00000394221.3
    Conserved Domains (1) summary
    cd00209
    Location:5182
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
  2. NM_176815.5NP_789785.1  dihydrofolate reductase 2, mitochondrial

    See identical proteins and their annotated locations for NP_789785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC130896, AW104373
    Consensus CDS
    CCDS2926.1
    UniProtKB/Swiss-Prot
    Q86XF0
    Related
    ENSP00000319170.2, ENST00000314636.3
    Conserved Domains (1) summary
    cd00209
    Location:5182
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    94057922..94063389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512537.3XP_011510839.1  dihydrofolate reductase 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011510839.1

    UniProtKB/Swiss-Prot
    Q86XF0
    Conserved Domains (1) summary
    cd00209
    Location:5182
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
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