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LIPH lipase H [ Homo sapiens (human) ]

Gene ID: 200879, updated on 8-Jul-2021

Summary

Official Symbol
LIPHprovided by HGNC
Official Full Name
lipase Hprovided by HGNC
Primary source
HGNC:HGNC:18483
See related
Ensembl:ENSG00000163898 MIM:607365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1
Summary
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 18.6), stomach (RPKM 18.4) and 12 other tissues See more
Orthologs
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Genomic context

See LIPH in Genome Data Viewer
Location:
3q27.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (185506262..185552661, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185224050..185270376, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 13 Neighboring gene uncharacterized LOC105374254 Neighboring gene transmembrane protein 41A Neighboring gene uncharacterized LOC107986055 Neighboring gene SUMO specific peptidase 2 Neighboring gene ribosomal protein L34 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lipase member H
Names
LPD lipase-related protein
lipase, member H
mPA-PLA1 alpha
membrane-associated phosphatidic acid-selective phospholipase A1-alpha
membrane-bound phosphatidic acid-selective phospholipase A1
phospholipase A(1)
phospholipase A1 member B
NP_640341.1
XP_006713592.1
XP_011510832.1
XP_011510833.1
XP_016861341.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012183.1 RefSeqGene

    Range
    4994..51320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139248.3NP_640341.1  lipase member H precursor

    See identical proteins and their annotated locations for NP_640341.1

    Status: REVIEWED

    Source sequence(s)
    AC099661, AK122651, BC064941, BI965988
    Consensus CDS
    CCDS3272.1
    UniProtKB/Swiss-Prot
    Q8WWY8
    Related
    ENSP00000296252.4, ENST00000296252.9
    Conserved Domains (1) summary
    cd00707
    Location:39303
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    185506262..185552661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512530.3XP_011510832.1  lipase member H isoform X3

    See identical proteins and their annotated locations for XP_011510832.1

    Conserved Domains (1) summary
    cd00707
    Location:1260
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
  2. XM_017005852.2XP_016861341.1  lipase member H isoform X2

    UniProtKB/TrEMBL
    A2IBA6
    Related
    ENSP00000396384.2, ENST00000424591.6
    Conserved Domains (1) summary
    cd00707
    Location:39269
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
  3. XM_006713529.4XP_006713592.1  lipase member H isoform X1

    Conserved Domains (1) summary
    cd00707
    Location:39273
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
  4. XM_011512531.3XP_011510833.1  lipase member H isoform X3

    See identical proteins and their annotated locations for XP_011510833.1

    Conserved Domains (1) summary
    cd00707
    Location:1260
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
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