Format

Send to:

Choose Destination

KCTD6 potassium channel tetramerization domain containing 6 [ Homo sapiens (human) ]

Gene ID: 200845, updated on 11-Sep-2019

Summary

Official Symbol
KCTD6provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 6provided by HGNC
Primary source
HGNC:HGNC:22235
See related
Ensembl:ENSG00000168301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCASH3
Expression
Ubiquitous expression in brain (RPKM 6.8), endometrium (RPKM 3.6) and 25 other tissues See more
Orthologs

Genomic context

See KCTD6 in Genome Data Viewer
Location:
3p14.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (58492096..58502360)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58477823..58488087)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase E1 beta subunit Neighboring gene uncharacterized LOC107986092 Neighboring gene acyl-CoA oxidase 2 Neighboring gene ribosomal protein L27 pseudogene 9 Neighboring gene uncharacterized LOC107984079 Neighboring gene family with sequence similarity 107 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ankyrin binding IDA
Inferred from Direct Assay
more info
PubMed 
cullin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular estrogen receptor signaling pathway TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
M band IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
BTB/POZ domain-containing protein KCTD6
Names
potassium channel tetramerisation domain containing 6
potassium channel tetramerization domain-containing protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128214.2NP_001121686.1  BTB/POZ domain-containing protein KCTD6

    See identical proteins and their annotated locations for NP_001121686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AA721100, BC022893, DA359951
    Consensus CDS
    CCDS2891.1
    UniProtKB/Swiss-Prot
    Q8NC69
    Related
    ENSP00000384948.3, ENST00000404589.8
    Conserved Domains (1) summary
    cd18394
    Location:10113
    BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)
  2. NM_153331.3NP_699162.3  BTB/POZ domain-containing protein KCTD6

    See identical proteins and their annotated locations for NP_699162.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AA721100, AK074934, BC022893
    Consensus CDS
    CCDS2891.1
    UniProtKB/Swiss-Prot
    Q8NC69
    Related
    ENSP00000347188.6, ENST00000355076.6
    Conserved Domains (1) summary
    cd18394
    Location:10113
    BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    58492096..58502360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264937.2XP_005264994.1  BTB/POZ domain-containing protein KCTD6 isoform X1

    See identical proteins and their annotated locations for XP_005264994.1

    UniProtKB/Swiss-Prot
    Q8NC69
    Conserved Domains (1) summary
    cd18394
    Location:10113
    BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)
Support Center