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SPRED2 sprouty related EVH1 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 200734, updated on 10-May-2020

Summary

Official Symbol
SPRED2provided by HGNC
Official Full Name
sprouty related EVH1 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:17722
See related
Ensembl:ENSG00000198369 MIM:609292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Spred-2
Summary
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 9.3), fat (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See SPRED2 in Genome Data Viewer
Location:
2p14
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (65307425..65432599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (65534580..65659733, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene VDAC2 pseudogene 5 Neighboring gene actin related protein 2 Neighboring gene uncharacterized LOC105374780 Neighboring gene uncharacterized LOC105374781 Neighboring gene DNAJB12 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
NHGRI GWA Catalog
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21897, FLJ31917, MGC163164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
stem cell factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
inactivation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inactivation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of DNA damage response, signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of protein deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sprouty-related, EVH1 domain-containing protein 2
Names
sprouty protein with EVH-1 domain 2, related sequence

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128210.2NP_001121682.1  sprouty-related, EVH1 domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001121682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK056479, AY299090, BC130292, DC335282
    Consensus CDS
    CCDS46308.1
    UniProtKB/Swiss-Prot
    Q7Z698
    UniProtKB/TrEMBL
    B3KPL5
    Related
    ENSP00000393697.2, ENST00000443619.6
    Conserved Domains (3) summary
    cd10574
    Location:9121
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:304402
    Sprouty; Sprouty protein (Spry)
    pfam08633
    Location:221292
    Rox3; Rox3 mediator complex subunit
  2. NM_181784.3NP_861449.2  sprouty-related, EVH1 domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_861449.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC012370, AK056479, AY299090, BC130292, DA102390
    Consensus CDS
    CCDS33211.1
    UniProtKB/Swiss-Prot
    Q7Z698
    UniProtKB/TrEMBL
    B3KPL5
    Related
    ENSP00000348753.4, ENST00000356388.9
    Conserved Domains (3) summary
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:307405
    Sprouty; Sprouty protein (Spry)
    pfam08633
    Location:224295
    Rox3; Rox3 mediator complex subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    65307425..65432599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264200.5XP_005264257.2  sprouty-related, EVH1 domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
  2. XM_005264202.5XP_005264259.1  sprouty-related, EVH1 domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
  3. XM_005264201.1XP_005264258.1  sprouty-related, EVH1 domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam05210
    Location:110208
    Sprouty; Sprouty protein (Spry)
  4. XM_017003576.1XP_016859065.1  sprouty-related, EVH1 domain-containing protein 2 isoform X1

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