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CREG2 cellular repressor of E1A stimulated genes 2 [ Homo sapiens (human) ]

Gene ID: 200407, updated on 25-Nov-2025
Official Symbol
CREG2provided by HGNC
Official Full Name
cellular repressor of E1A stimulated genes 2provided by HGNC
Primary source
HGNC:HGNC:14272
See related
Ensembl:ENSG00000175874 MIM:618540; AllianceGenome:HGNC:14272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward brain (RPKM 23.3) See more
Orthologs
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See CREG2 in Genome Data Viewer
Location:
2q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101345550..101387503, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101804250..101846207, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101962012..102003965, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 149 Neighboring gene uncharacterized LOC124906052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11825 Neighboring gene uncharacterized LOC105373512 Neighboring gene microRNA 5696 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:101946330-101947106 and GRCh37_chr2:101947107-101947883 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101955361-101956145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101986959-101987460 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11826 Neighboring gene regulatory factor X8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102075751-102076344 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:102080348-102081547 Neighboring gene NANOG hESC enhancer GRCh37_chr2:102083658-102084245 Neighboring gene long intergenic non-protein coding RNA 1870

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. Kunita R, et al. Genomics, 2002 Nov. PMID 12408961
  2. USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c. Yao Y, et al. Oncogenesis, 2022 Jun 2. PMID 35654790, Free PMC Article
  3. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CREG2 are putative secreted glycoproteins and may be novel neuronal extracellular molecules.
    Title: Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
protein CREG2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153836.4 → NP_722578.1  protein CREG2 precursor

    See identical proteins and their annotated locations for NP_722578.1

    Status: VALIDATED

    Source sequence(s)
    AB046109, AC099797
    Consensus CDS
    CCDS2052.1
    UniProtKB/Swiss-Prot
    Q86X03, Q8IUH2, Q8N540, Q8N9E3
    Related
    ENSP00000315203.4, ENST00000324768.6
    Conserved Domains (1) summary
    pfam13883
    Location:118 → 284
    Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101345550..101387503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510777.3 → XP_011509079.2  protein CREG2 isoform X2

    UniProtKB/TrEMBL
    Q580X0

  2. XM_017003565.2 → XP_016859054.2  protein CREG2 isoform X1

    UniProtKB/TrEMBL
    Q580X0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    101804250..101846207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340948.1 → XP_054196923.1  protein CREG2 isoform X2

    UniProtKB/TrEMBL
    Q580X0

  2. XM_054340947.1 → XP_054196922.1  protein CREG2 isoform X1

    UniProtKB/TrEMBL
    Q580X0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IUH2.1 GenPept UniProtKB/Swiss-Prot:Q8IUH2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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