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CREG2 cellular repressor of E1A stimulated genes 2 [ Homo sapiens (human) ]

Gene ID: 200407, updated on 25-Jan-2022

Summary

Official Symbol
CREG2provided by HGNC
Official Full Name
cellular repressor of E1A stimulated genes 2provided by HGNC
Primary source
HGNC:HGNC:14272
See related
Ensembl:ENSG00000175874 MIM:618540; AllianceGenome:HGNC:14272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward brain (RPKM 23.3) See more
Orthologs
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Genomic context

See CREG2 in Genome Data Viewer
Location:
2q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (101345550..101387970, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101962012..102003965, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373512 Neighboring gene microRNA 5696 Neighboring gene Sharpr-MPRA regulatory region 6404 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial pseudogene Neighboring gene regulatory factor X8 Neighboring gene long intergenic non-protein coding RNA 1870

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153836.4NP_722578.1  protein CREG2 precursor

    See identical proteins and their annotated locations for NP_722578.1

    Status: VALIDATED

    Source sequence(s)
    AB046109, AC099797
    Consensus CDS
    CCDS2052.1
    UniProtKB/Swiss-Prot
    Q8IUH2
    Related
    ENSP00000315203.4, ENST00000324768.6
    Conserved Domains (1) summary
    pfam13883
    Location:118284
    Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    101345550..101387970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003565.1XP_016859054.1  protein CREG2 isoform X1

  2. XM_011510777.2XP_011509079.1  protein CREG2 isoform X2

    Conserved Domains (1) summary
    cl00381
    Location:193280
    PNPOx/FlaRed_like; Pyridoxine 5'-phosphate (PNP) oxidase-like and flavin reductase-like proteins
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