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CREG2 cellular repressor of E1A stimulated genes 2 [ Homo sapiens (human) ]

Gene ID: 200407, updated on 27-Nov-2024

Summary

Official Symbol
CREG2provided by HGNC
Official Full Name
cellular repressor of E1A stimulated genes 2provided by HGNC
Primary source
HGNC:HGNC:14272
See related
Ensembl:ENSG00000175874 MIM:618540; AllianceGenome:HGNC:14272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward brain (RPKM 23.3) See more
Orthologs
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Genomic context

See CREG2 in Genome Data Viewer
Location:
2q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101345550..101387503, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101804250..101846207, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101962012..102003965, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 149 Neighboring gene uncharacterized LOC124906052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11825 Neighboring gene uncharacterized LOC105373512 Neighboring gene microRNA 5696 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:101946330-101947106 and GRCh37_chr2:101947107-101947883 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101955361-101956145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101986959-101987460 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11826 Neighboring gene regulatory factor X8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102075751-102076344 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:102080348-102081547 Neighboring gene NANOG hESC enhancer GRCh37_chr2:102083658-102084245 Neighboring gene long intergenic non-protein coding RNA 1870

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153836.4NP_722578.1  protein CREG2 precursor

    See identical proteins and their annotated locations for NP_722578.1

    Status: VALIDATED

    Source sequence(s)
    AB046109, AC099797
    Consensus CDS
    CCDS2052.1
    UniProtKB/Swiss-Prot
    Q86X03, Q8IUH2, Q8N540, Q8N9E3
    Related
    ENSP00000315203.4, ENST00000324768.6
    Conserved Domains (1) summary
    pfam13883
    Location:118284
    Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101345550..101387503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510777.3XP_011509079.2  protein CREG2 isoform X2

  2. XM_017003565.2XP_016859054.2  protein CREG2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    101804250..101846207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340948.1XP_054196923.1  protein CREG2 isoform X2

  2. XM_054340947.1XP_054196922.1  protein CREG2 isoform X1