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ELK3 ETS transcription factor ELK3 [ Homo sapiens (human) ]

Gene ID: 2004, updated on 13-Mar-2020

Summary

Official Symbol
ELK3provided by HGNC
Official Full Name
ETS transcription factor ELK3provided by HGNC
Primary source
HGNC:HGNC:3325
See related
Ensembl:ENSG00000111145 MIM:600247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERP; NET; SAP2; SAP-2
Summary
This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Annotation information
Note: NET is an alias on both SLC6A2 (Gene ID: 6530, "norepinephrine transporter") and ELK3 (Gene ID: 2004). [01 Jun 2018]
Expression
Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 22.8) and 24 other tissues See more
Orthologs

Genomic context

See ELK3 in Genome Data Viewer
Location:
12q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (96194375..96269824)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96588207..96661606)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2452 Neighboring gene uncharacterized LOC105369925 Neighboring gene uncharacterized LOC107984546 Neighboring gene cyclin dependent kinase 17 Neighboring gene RNA, U4 small nuclear 24, pseudogene Neighboring gene RN7SK pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
ETS domain-containing protein Elk-3
Names
ELK3, ETS transcription factor
ELK3, ETS-domain protein (SRF accessory protein 2)
ETS-related protein ERP
ETS-related protein NET
SRF accessory protein 2
serum response factor accessory protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303511.2NP_001290440.1  ETS domain-containing protein Elk-3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exon in the 5' UTR and coding region and uses an alternate 5' most exon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC008149, AL705041, AW575797
  2. NM_005230.4NP_005221.2  ETS domain-containing protein Elk-3 isoform 1

    See identical proteins and their annotated locations for NP_005221.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008149, AK312694, AW575797, DA754301
    Consensus CDS
    CCDS9060.1
    UniProtKB/Swiss-Prot
    P41970
    UniProtKB/TrEMBL
    A0A024RBE2
    Related
    ENSP00000228741.3, ENST00000228741.8
    Conserved Domains (1) summary
    smart00413
    Location:1988
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    96194375..96269824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719275.3XP_006719338.1  ETS domain-containing protein Elk-3 isoform X1

    See identical proteins and their annotated locations for XP_006719338.1

    UniProtKB/Swiss-Prot
    P41970
    UniProtKB/TrEMBL
    A0A024RBE2
    Conserved Domains (1) summary
    smart00413
    Location:1988
    ETS; erythroblast transformation specific domain
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