KRTCAP2 keratinocyte associated protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KRTCAP2provided by HGNC
Official Full Name: keratinocyte associated protein 2provided by HGNC
Primary source: HGNC:HGNC:28942
See related: Ensembl:ENSG00000163463 MIM:619029; AllianceGenome:HGNC:28942
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KCP2
Summary: Enables enzyme activator activity and protein-macromolecule adaptor activity. Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in testis (RPKM 48.6), fat (RPKM 46.3) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (155169408..155173304, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (154309025..154312920, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (155141884..155145780, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma.
Title: KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma.
DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase STT3A and the endoplasmic reticulum translocon.
Title: DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon.
data strongly support the proposal that KCP2 is a newly identified subunit of the N-glycosylation machinery present in a subset of eukaryotes
Title: Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-11760 (e-PCR)
- UniSTS:5651

D15S1477 (e-PCR)
- UniSTS:474482

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables enzyme activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	EXP Inferred from Experiment more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	EXP Inferred from Experiment more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
part_of oligosaccharyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of oligosaccharyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of oligosaccharyltransferase complex	NAS Non-traceable Author Statement more info	PubMed
part_of oligosaccharyltransferase complex A	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

Names: KCP-2; keratinocytes associated protein 2; oligosaccharyl transferase subunit KCP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173852.4 → NP_776251.2 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

Status: VALIDATED

Source sequence(s)

AL607067

Consensus CDS

CCDS1096.2

UniProtKB/Swiss-Prot

B2R4Q1, Q6PG45, Q86XW2, Q8IWS4, Q8N6L1

UniProtKB/TrEMBL

A0ACI8T4M4

Related

ENSP00000295682.5, ENST00000295682.6

Conserved Domains (1) summary

pfam09775
Location:3 → 131

Keratin_assoc; Keratinocyte-associated protein 2