Polr1d polymerase (RNA) I polypeptide D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Polr1dprovided by MGI
Official Full Name: polymerase (RNA) I polypeptide Dprovided by MGI
Primary source: MGI:MGI:108403
See related: Ensembl:ENSMUSG00000029642 AllianceGenome:MGI:108403
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AC19; RPA16; Rpo1-3; 1110003G10Rik
Summary: This gene encodes an RNA polymerase subunit that is a component of both the RNA polymerase I and RNA polymerase III complexes. RNA polymerase I is associated with transcription of pre-ribosomal RNAs, while RNA polymerase III is associated with transcription of small RNAs. Pseudogenes of this gene have been defined on chromosomes 4 and 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Expression: Ubiquitous expression in testis adult (RPKM 34.1), placenta adult (RPKM 28.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 G3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (147013525..147048171)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (147076715..147111361)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice.
Title: Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135944 (e-PCR)
- UniSTS:209940

RH127056 (e-PCR)
- UniSTS:209783

Homology

Homologs of the Polr1d gene: The Polr1d gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 193 organisms have orthologs with human gene Polr1d
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase I activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of RNA polymerase I complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerases I and III subunit RPAC2

Names: DNA-directed RNA polymerase I 16 kDa polypeptide; RNA polymerase 1-3; RNA polymerases I and III subunit AC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009087.2 → NP_033113.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform 1

See identical proteins and their annotated locations for NP_033113.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).

Source sequence(s)

AA023617, AK002811, BM948930

Consensus CDS

CCDS19876.1

UniProtKB/Swiss-Prot

P97304

UniProtKB/TrEMBL

Q545W2

Related

ENSMUSP00000058355.4, ENSMUST00000050970.4

Conserved Domains (1) summary

cd07029
Location:30 → 114

RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
NM_181730.4 → NP_859419.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform 2

See identical proteins and their annotated locations for NP_859419.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

BC087884, BF462386, BM948930

Consensus CDS

CCDS39397.1

UniProtKB/TrEMBL

Q9D1M1

Related

ENSMUSP00000106186.2, ENSMUST00000110557.5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

147013525..147048171

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254228.1 → XP_030110088.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

UniProtKB/TrEMBL

Q9D1M1
XM_030254231.1 → XP_030110091.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

UniProtKB/TrEMBL

Q9D1M1
XM_036164932.1 → XP_036020825.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

UniProtKB/TrEMBL

Q9D1M1
XM_030254230.1 → XP_030110090.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

UniProtKB/TrEMBL

Q9D1M1
XM_030254232.1 → XP_030110092.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

UniProtKB/TrEMBL

Q9D1M1
XM_030254229.1 → XP_030110089.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

UniProtKB/TrEMBL

Q9D1M1
XM_030254233.1 → XP_030110093.1 DNA-directed RNA polymerases I and III subunit RPAC2 isoform X2