Format

Send to:

Choose Destination

PLD5 phospholipase D family member 5 [ Homo sapiens (human) ]

Gene ID: 200150, updated on 1-Jun-2020

Summary

Official Symbol
PLD5provided by HGNC
Official Full Name
phospholipase D family member 5provided by HGNC
Primary source
HGNC:HGNC:26879
See related
Ensembl:ENSG00000180287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLDC
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See PLD5 in Genome Data Viewer
Location:
1q43
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (242082986..242530546, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (242251689..242687998, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1139, pseudogene Neighboring gene tubulin beta 8 class VIII pseudogene 6 Neighboring gene tripartite motif containing 39 pseudogene Neighboring gene RN7SK pseudogene 12 Neighboring gene uncharacterized LOC105373235 Neighboring gene zinc finger protein 532 pseudogene Neighboring gene DEAD-box helicase 55 pseudogene Neighboring gene ribosomal protein L10a pseudogene 5 Neighboring gene uncharacterized LOC105373234 Neighboring gene uncharacterized LOC107985466 Neighboring gene ribosomal L24 domain containing 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
NHGRI GWA Catalog
Genetics of coronary artery calcification among African Americans, a meta-analysis.
NHGRI GWA Catalog
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40773, MGC120565, MGC120566, MGC120567

Gene Ontology Provided by GOA

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inactive phospholipase D5
Names
inactive PLD 5
inactive choline phosphatase 5
inactive phosphatidylcholine-hydrolyzing phospholipase D5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195811.1NP_001182740.1  inactive phospholipase D5 isoform 2

    See identical proteins and their annotated locations for NP_001182740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate splice junction at the 3' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL591686, AY461578
    Consensus CDS
    CCDS55692.1
    UniProtKB/Swiss-Prot
    Q8N7P1
    Related
    ENSP00000401285.1, ENST00000427495.5
    Conserved Domains (3) summary
    cd09146
    Location:49211
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:247440
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    PHA02820
    Location:42465
    PHA02820; phospholipase-D-like protein; Provisional
  2. NM_001195812.2NP_001182741.1  inactive phospholipase D5 isoform 3

    See identical proteins and their annotated locations for NP_001182741.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK091691, AL591686, AY461578
    UniProtKB/Swiss-Prot
    Q8N7P1
    Conserved Domains (3) summary
    cd09149
    Location:101294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    pfam13091
    Location:125286
    PLDc_2; PLD-like domain
    cl15239
    Location:165
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  3. NM_001320272.2NP_001307201.1  inactive phospholipase D5 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. It encodes isoform 4, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK098092, AL133851, AL445704, AL591686, BU581400
    UniProtKB/Swiss-Prot
    Q8N7P1
    UniProtKB/TrEMBL
    A0A024R3S7
    Conserved Domains (3) summary
    cd09146
    Location:19181
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:217410
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    PHA02820
    Location:20435
    PHA02820; phospholipase-D-like protein; Provisional
  4. NM_001372062.1NP_001358991.1  inactive phospholipase D5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL360271, AL445704, AL583845, AL591686
    Consensus CDS
    CCDS1621.2
    Related
    ENSP00000440896.1, ENST00000536534.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    242082986..242530546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544120.2XP_011542422.1  inactive phospholipase D5 isoform X6

    See identical proteins and their annotated locations for XP_011542422.1

    UniProtKB/Swiss-Prot
    Q8N7P1
    Conserved Domains (3) summary
    cd09149
    Location:101294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    pfam13091
    Location:125286
    PLDc_2; PLD-like domain
    cl15239
    Location:165
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  2. XM_017000569.1XP_016856058.1  inactive phospholipase D5 isoform X6

    UniProtKB/Swiss-Prot
    Q8N7P1
    Conserved Domains (3) summary
    cd09149
    Location:101294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    pfam13091
    Location:125286
    PLDc_2; PLD-like domain
    cl15239
    Location:165
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  3. XM_011544119.2XP_011542421.2  inactive phospholipase D5 isoform X5

  4. XM_011544121.2XP_011542423.1  inactive phospholipase D5 isoform X6

    See identical proteins and their annotated locations for XP_011542423.1

    UniProtKB/Swiss-Prot
    Q8N7P1
    Conserved Domains (3) summary
    cd09149
    Location:101294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    pfam13091
    Location:125286
    PLDc_2; PLD-like domain
    cl15239
    Location:165
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  5. XM_017000570.2XP_016856059.1  inactive phospholipase D5 isoform X6

    UniProtKB/Swiss-Prot
    Q8N7P1
    Conserved Domains (3) summary
    cd09149
    Location:101294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    pfam13091
    Location:125286
    PLDc_2; PLD-like domain
    cl15239
    Location:165
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  6. XM_011544122.3XP_011542424.1  inactive phospholipase D5 isoform X6

    See identical proteins and their annotated locations for XP_011542424.1

    UniProtKB/Swiss-Prot
    Q8N7P1
    Conserved Domains (3) summary
    cd09149
    Location:101294
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    pfam13091
    Location:125286
    PLDc_2; PLD-like domain
    cl15239
    Location:165
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  7. XM_011544115.2XP_011542417.1  inactive phospholipase D5 isoform X3

    See identical proteins and their annotated locations for XP_011542417.1

    UniProtKB/Swiss-Prot
    Q8N7P1
    Conserved Domains (2) summary
    cd09146
    Location:20182
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:218411
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
  8. XM_011544116.2XP_011542418.1  inactive phospholipase D5 isoform X3

    See identical proteins and their annotated locations for XP_011542418.1

    UniProtKB/Swiss-Prot
    Q8N7P1
    Conserved Domains (2) summary
    cd09146
    Location:20182
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:218411
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
  9. XM_017000567.2XP_016856056.1  inactive phospholipase D5 isoform X4

    UniProtKB/Swiss-Prot
    Q8N7P1
    UniProtKB/TrEMBL
    A0A024R3S7
    Conserved Domains (3) summary
    cd09146
    Location:19181
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:217410
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    PHA02820
    Location:20435
    PHA02820; phospholipase-D-like protein; Provisional
  10. XM_017000568.2XP_016856057.1  inactive phospholipase D5 isoform X4

    UniProtKB/Swiss-Prot
    Q8N7P1
    UniProtKB/TrEMBL
    A0A024R3S7
    Conserved Domains (3) summary
    cd09146
    Location:19181
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:217410
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
    PHA02820
    Location:20435
    PHA02820; phospholipase-D-like protein; Provisional
  11. XM_024453867.1XP_024309635.1  inactive phospholipase D5 isoform X2

    Conserved Domains (2) summary
    cd09146
    Location:68230
    PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
    cd09149
    Location:266459
    PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152666.2: Suppressed sequence

    Description
    NM_152666.2: This RefSeq was removed because currently there is support for the protein but not for the transcript.
Support Center