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DYNLT5 dynein light chain Tctex-type family member 5 [ Homo sapiens (human) ]

Gene ID: 200132, updated on 3-Mar-2026
Official Symbol
DYNLT5provided by HGNC
Official Full Name
dynein light chain Tctex-type family member 5provided by HGNC
Primary source
HGNC:HGNC:26882
See related
Ensembl:ENSG00000152760 MIM:619994; AllianceGenome:HGNC:26882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCTEX1D1
Summary
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in placenta (RPKM 2.7), liver (RPKM 2.4) and 14 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See DYNLT5 in Genome Data Viewer
Location:
1p31.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (66752459..66779047)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (66629993..66656589)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (67218142..67244730)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SH3GL interacting endocytic adaptor 1 Neighboring gene uncharacterized LOC124904196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1166 Neighboring gene microRNA 3117 Neighboring gene insulin like 5 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1167

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy. Spitali P, et al. Eur J Hum Genet, 2020 Jun. PMID 31896777, Free PMC Article
  2. ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. Cho KJ, et al. PLoS Genet, 2018 Mar. PMID 29601588, Free PMC Article
  3. DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Jiao F, et al. J Proteome Res, 2024 Aug 2. PMID 38334954, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy.
    Title: TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ40873, MGC125768

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
dynein light chain Tctex-type 5
Names
Tctex1 domain containing 1
tctex1 domain-containing protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152665.3 → NP_689878.2  dynein light chain Tctex-type 5

    See identical proteins and their annotated locations for NP_689878.2

    Status: VALIDATED

    Source sequence(s)
    AI016360, AK098192, AL354978
    Consensus CDS
    CCDS633.1
    UniProtKB/Swiss-Prot
    Q06YR9, Q5VYE1, Q8N7M0
    Related
    ENSP00000282670.2, ENST00000282670.7
    Conserved Domains (1) summary
    pfam03645
    Location:81 → 177
    Tctex-1; Tctex-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    66752459..66779047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448667.1 → XP_047304623.1  dynein light chain Tctex-type 5 isoform X2

  2. XM_047448668.1 → XP_047304624.1  dynein light chain Tctex-type 5 isoform X2

  3. XM_047448675.1 → XP_047304631.1  dynein light chain Tctex-type 5 isoform X2

  4. XM_047448666.1 → XP_047304622.1  dynein light chain Tctex-type 5 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    66629993..66656589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334936.1 → XP_054190911.1  dynein light chain Tctex-type 5 isoform X2

  2. XM_054334937.1 → XP_054190912.1  dynein light chain Tctex-type 5 isoform X2

  3. XM_054334938.1 → XP_054190913.1  dynein light chain Tctex-type 5 isoform X2

  4. XM_054334935.1 → XP_054190910.1  dynein light chain Tctex-type 5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N7M0.2 GenPept UniProtKB/Swiss-Prot:Q8N7M0

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