Format

Send to:

Choose Destination

SLC5A9 solute carrier family 5 member 9 [ Homo sapiens (human) ]

Gene ID: 200010, updated on 18-Aug-2020

Summary

Official Symbol
SLC5A9provided by HGNC
Official Full Name
solute carrier family 5 member 9provided by HGNC
Primary source
HGNC:HGNC:22146
See related
Ensembl:ENSG00000117834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGLT4
Expression
Biased expression in duodenum (RPKM 15.3), small intestine (RPKM 14.5) and 4 other tissues See more
Orthologs

Genomic context

See SLC5A9 in Genome Data Viewer
Location:
1p33
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (48221113..48248644)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (48688339..48714316)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2794 Neighboring gene cytochrome P450 family 46 subfamily A member 4, pseudogene Neighboring gene Skint1 like (pseudogene) Neighboring gene spermatogenesis associated 6 Neighboring gene protein phosphatase 1 regulatory subunit 8 pseudogene 1 Neighboring gene RNA, U6 small nuclear 723, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC132517, MGC132523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
low-affinity glucose:sodium symporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
hexose transmembrane transport TAS
Traceable Author Statement
more info
 
sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/glucose cotransporter 4
Names
Na(+)/glucose cotransporter 4
hSGLT4
solute carrier family 5 (sodium/glucose cotransporter), member 9
solute carrier family 5 (sodium/sugar cotransporter), member 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011547.3NP_001011547.2  sodium/glucose cotransporter 4 isoform 2

    See identical proteins and their annotated locations for NP_001011547.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AI767388, AL109659, BC104857
    Consensus CDS
    CCDS30709.2
    UniProtKB/Swiss-Prot
    Q2M3M2
    Related
    ENSP00000401730.2, ENST00000438567.6
    Conserved Domains (1) summary
    cd11488
    Location:37681
    SLC5sbd_SGLT4; Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain
  2. NM_001135181.2NP_001128653.1  sodium/glucose cotransporter 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI767388, AL109659, BC104857, BX648549
    Consensus CDS
    CCDS44136.1
    UniProtKB/Swiss-Prot
    Q2M3M2
    Related
    ENSP00000236495.5, ENST00000236495.9
    Conserved Domains (1) summary
    cd11488
    Location:37706
    SLC5sbd_SGLT4; Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    48221113..48248644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540929.2XP_011539231.1  sodium/glucose cotransporter 4 isoform X7

    Conserved Domains (1) summary
    cl00456
    Location:37444
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_017000558.1XP_016856047.1  sodium/glucose cotransporter 4 isoform X4

  3. XM_011540925.2XP_011539227.1  sodium/glucose cotransporter 4 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:37641
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_011540924.2XP_011539226.1  sodium/glucose cotransporter 4 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:37719
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_011540926.3XP_011539228.1  sodium/glucose cotransporter 4 isoform X3

    Related
    ENST00000493837.6
    Conserved Domains (1) summary
    cl00456
    Location:130625
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. XM_011540928.1XP_011539230.1  sodium/glucose cotransporter 4 isoform X6

    Conserved Domains (1) summary
    cl00456
    Location:1475
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  7. XM_011540927.1XP_011539229.1  sodium/glucose cotransporter 4 isoform X5

    Conserved Domains (1) summary
    cl00456
    Location:91586
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_946573.2 RNA Sequence

Support Center