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ELF4 E74 like ETS transcription factor 4 [ Homo sapiens (human) ]

Gene ID: 2000, updated on 11-Sep-2019

Summary

Official Symbol
ELF4provided by HGNC
Official Full Name
E74 like ETS transcription factor 4provided by HGNC
Primary source
HGNC:HGNC:3319
See related
Ensembl:ENSG00000102034 MIM:300775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEF; ELFR
Summary
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Expression
Broad expression in bone marrow (RPKM 18.8), placenta (RPKM 12.9) and 21 other tissues See more
Orthologs

Genomic context

See ELF4 in Genome Data Viewer
Location:
Xq26.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (130064874..130110891, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129198895..129244688, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373335 Neighboring gene UTP14A small subunit processome component Neighboring gene BCL6 corepressor like 1 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene apoptosis inducing factor mitochondria associated 1 Neighboring gene zinc finger protein 280C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of E74-like factor 4 (ELF4) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
NK T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
natural killer cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ETS-related transcription factor Elf-4
Names
E74-like factor 4 (ets domain transcription factor)
myeloid Elf-1-like factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016388.1 RefSeqGene

    Range
    5001..50794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_335

mRNA and Protein(s)

  1. NM_001127197.2NP_001120669.1  ETS-related transcription factor Elf-4

    See identical proteins and their annotated locations for NP_001120669.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK314972, AL136450, BC017194, Z81363
    Consensus CDS
    CCDS14617.1
    UniProtKB/Swiss-Prot
    Q99607
    Related
    ENSP00000338608.7, ENST00000335997.11
    Conserved Domains (2) summary
    smart00413
    Location:208290
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2104
    Elf-1_N; Transcription factor protein N terminal
  2. NM_001421.3NP_001412.1  ETS-related transcription factor Elf-4

    See identical proteins and their annotated locations for NP_001412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL136450, CD364651, CN314421, DN999740, U32645
    Consensus CDS
    CCDS14617.1
    UniProtKB/Swiss-Prot
    Q99607
    Related
    ENSP00000311280.5, ENST00000308167.9
    Conserved Domains (2) summary
    smart00413
    Location:208290
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2104
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    130064874..130110891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531307.3XP_011529609.1  ETS-related transcription factor Elf-4 isoform X2

    Conserved Domains (2) summary
    pfam00178
    Location:143222
    Ets; Ets-domain
    pfam12310
    Location:136
    Elf-1_N; Transcription factor protein N terminal
  2. XM_005262389.3XP_005262446.1  ETS-related transcription factor Elf-4 isoform X1

    See identical proteins and their annotated locations for XP_005262446.1

    UniProtKB/Swiss-Prot
    Q99607
    Conserved Domains (2) summary
    smart00413
    Location:208290
    ETS; erythroblast transformation specific domain
    pfam12310
    Location:2104
    Elf-1_N; Transcription factor protein N terminal
  3. XM_011531308.3XP_011529610.1  ETS-related transcription factor Elf-4 isoform X3

    Conserved Domains (2) summary
    pfam00178
    Location:134213
    Ets; Ets-domain
    pfam12310
    Location:627
    Elf-1_N; Transcription factor protein N terminal
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