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CYP4Z1 cytochrome P450 family 4 subfamily Z member 1 [ Homo sapiens (human) ]

Gene ID: 199974, updated on 10-Dec-2024

Summary

Official Symbol
CYP4Z1provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily Z member 1provided by HGNC
Primary source
HGNC:HGNC:20583
See related
Ensembl:ENSG00000186160 MIM:618953; AllianceGenome:HGNC:20583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP4A20
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CYP4Z1 in Genome Data Viewer
Location:
1p33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (47055525..47118318)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46932944..46995763)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47532903..47583990)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily X member 1 Neighboring gene cytochrome P450 family 4 subfamily A member 44, pseudogene Neighboring gene uncharacterized LOC124904172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47489635-47490135 Neighboring gene tubulin alpha pseudogene 9 Neighboring gene CYP4A22 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47569786-47570506 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:47573513-47574122 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:47578681-47579223 Neighboring gene cytochrome P450 family 4 subfamily A member 22 Neighboring gene MT-ND1 pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General protein information

Preferred Names
cytochrome P450 4Z1
Names
CYPIVZ1
cytochrome P450, family 4, subfamily Z, polypeptide 1
laurate 7-monooxygenase
NP_835235.1
XP_024309624.1
XP_054190878.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007967.1 RefSeqGene

    Range
    4744..55831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178134.3NP_835235.1  cytochrome P450 4Z1

    See identical proteins and their annotated locations for NP_835235.1

    Status: REVIEWED

    Source sequence(s)
    AL135960, AL450996
    Consensus CDS
    CCDS545.1
    UniProtKB/Swiss-Prot
    Q5VVE4, Q86W10
    Related
    ENSP00000334246.3, ENST00000334194.4
    Conserved Domains (1) summary
    pfam00067
    Location:47500
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    47055525..47118318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453856.2XP_024309624.1  cytochrome P450 4Z1 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:9462
    p450; Cytochrome P450

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    46932944..46995763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334903.1XP_054190878.1  cytochrome P450 4Z1 isoform X1