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U2AF1L4 U2 small nuclear RNA auxiliary factor 1 like 4 [ Homo sapiens (human) ]

Gene ID: 199746, updated on 23-Nov-2021

Summary

Official Symbol
U2AF1L4provided by HGNC
Official Full Name
U2 small nuclear RNA auxiliary factor 1 like 4provided by HGNC
Primary source
HGNC:HGNC:23020
See related
Ensembl:ENSG00000161265 MIM:601080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U2af26; U2AF1L3; U2AF1RS3; U2AF1-RS3; U2AF1L3V1
Expression
Ubiquitous expression in spleen (RPKM 9.3), thyroid (RPKM 9.1) and 25 other tissues See more
Orthologs
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Genomic context

See U2AF1L4 in Genome Data Viewer
Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35742464..35745418, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36233365..36236319, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene lysine methyltransferase 2B Neighboring gene IGF like family receptor 1 Neighboring gene presenilin enhancer, gamma-secretase subunit Neighboring gene lin-37 DREAM MuvB core complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18593, FLJ35525, MGC33901

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
splicing factor U2AF 26 kDa subunit
Names
U2 auxiliary factor 26
U2 small nuclear RNA auxiliary factor 1-like 3
U2 small nuclear RNA auxiliary factor 1-like protein 3
U2 small nuclear RNA auxiliary factor 1-like protein 4
U2(RNU2) small nuclear RNA auxiliary factor 1-like 3
U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3
U2AF1-like 4
U2AF1-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040425.3NP_001035515.1  splicing factor U2AF 26 kDa subunit isoform 1

    See identical proteins and their annotated locations for NP_001035515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate splice site in the coding region, which results in reading frameshift, compared to variant 2. The resulting isoform (1) is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AI767079, AY569437, DC415103
    Consensus CDS
    CCDS42551.1
    UniProtKB/Swiss-Prot
    Q8WU68
    Related
    ENSP00000368258.2, ENST00000378975.8
    Conserved Domains (2) summary
    pfam00642
    Location:110136
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17169
    Location:41107
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001369824.2NP_001356753.1  splicing factor U2AF 26 kDa subunit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AD000671
    Conserved Domains (2) summary
    pfam00642
    Location:1339
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17169
    Location:41102
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_144987.4NP_659424.2  splicing factor U2AF 26 kDa subunit isoform 2

    See identical proteins and their annotated locations for NP_659424.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AI767079, AY569437, BC010865, BC021186, DC415103
    Consensus CDS
    CCDS12473.1
    UniProtKB/Swiss-Prot
    Q8WU68
    Related
    ENSP00000292879.4, ENST00000292879.9
    Conserved Domains (2) summary
    pfam00642
    Location:1339
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17169
    Location:41102
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. NR_110173.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an additional exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI767079, BC010865, BM696851
  2. NR_163169.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AD000671
    Related
    ENST00000592913.5
  3. NR_163170.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AD000671
    Related
    ENST00000587987.5
  4. NR_163171.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AD000671
  5. NR_163172.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AD000671
  6. NR_163173.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AD000671

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35742464..35745418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_110171.1: Suppressed sequence

    Description
    NR_110171.1: This RefSeq was removed because currently there is insufficient support for the transcript.
  2. NR_110172.1: Suppressed sequence

    Description
    NR_110172.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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