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THAP8 THAP domain containing 8 [ Homo sapiens (human) ]

Gene ID: 199745, updated on 23-Nov-2021

Summary

Official Symbol
THAP8provided by HGNC
Official Full Name
THAP domain containing 8provided by HGNC
Primary source
HGNC:HGNC:23191
See related
Ensembl:ENSG00000161277 MIM:612536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 4.3), endometrium (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

See THAP8 in Genome Data Viewer
Location:
19q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (36034984..36054762, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36525886..36545664, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927572 Neighboring gene alkB homolog 6 Neighboring gene CAP-Gly domain containing linker protein 3 Neighboring gene RNY5 pseudogene 10 Neighboring gene WD repeat domain 62 Neighboring gene ovo like zinc finger 3 Neighboring gene RNA polymerase II subunit I

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
THAP domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331102.2NP_001318031.1  THAP domain-containing protein 8 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC002116, AD000813, JQ410992
    UniProtKB/TrEMBL
    H9CWI5
  2. NM_001331103.2NP_001318032.1  THAP domain-containing protein 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC002116, AK296640, JQ410992
    UniProtKB/TrEMBL
    B4DKM9, H9CWI5
  3. NM_001331104.1NP_001318033.1  THAP domain-containing protein 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC002116, AD000813
    UniProtKB/TrEMBL
    B4DKM9
  4. NM_152658.3NP_689871.1  THAP domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_689871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC002116, AK093048
    Consensus CDS
    CCDS33000.1
    UniProtKB/Swiss-Prot
    Q8NA92
    Related
    ENSP00000292894.1, ENST00000292894.2
    Conserved Domains (1) summary
    smart00980
    Location:486
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

RNA

  1. NR_138539.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC002116, AK297630, JQ410992

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    36034984..36054762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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