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CADM4 cell adhesion molecule 4 [ Homo sapiens (human) ]

Gene ID: 199731, updated on 9-Aug-2026
Official Symbol
CADM4provided by HGNC
Official Full Name
cell adhesion molecule 4provided by HGNC
Primary source
HGNC:HGNC:30825
See related
Ensembl:ENSG00000105767 MIM:609744; AllianceGenome:HGNC:30825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NECL4; TSLL2; IGSF4C; Necl-4; synCAM4
Summary
Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in brain (RPKM 59.7), kidney (RPKM 14.7) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CADM4 in Genome Data Viewer
Location:
19q13.31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43622368..43641984, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46444027..46463643, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44126520..44144002, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14730 Neighboring gene zinc finger protein 576 Neighboring gene zinc finger protein 428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44123140-44123790 Neighboring gene uncharacterized LOC105372411 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44127716-44128216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44128217-44128717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10725 Neighboring gene plasminogen activator, urokinase receptor Neighboring gene RNA, 7SL, cytoplasmic 368, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10726 Neighboring gene uncharacterized LOC124904724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14732 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44183469-44183968

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas. Jang SM, et al. J Clin Pathol, 2012 Oct. PMID 22718847
  2. Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast. Jang SM, et al. J Clin Pathol, 2013 Aug. PMID 23559354
  3. Identification of protein markers in patients infected with Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax. Mu AK, et al. Int J Mol Sci, 2014 Nov 3. PMID 25372941, Free PMC Article
  4. Involvement of membrane skeletal molecules in the Schmidt-Lanterman incisure in Schwann cells. Terada N, et al. Med Mol Morphol, 2016 Mar. PMID 26541343
  5. Clinicopathological significance of Necl-4 expression in pancreatic ductal adenocarcinoma. Kawanishi A, et al. J Clin Pathol, 2017 Jul. PMID 27980052

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
    Title: Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
  2. There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas
    Title: Necl 4 and RNase 5 Are Important Biomarkers for Gastric and Colon Adenocarcinomas.
  3. Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma.
    Title: Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.
  4. The results suggest that Necl-4 enhances VEGF-induced activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the phosphorylation and internalization of VEGFR2.
    Title: Necl-4 enhances the PLCγ-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2.
  5. Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13
    Title: The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
  6. results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly
    Title: Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
  7. Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters.
    Title: Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast.
  8. Cadm4 regulates the growth of the myelin unit and the organization of the underlying axonal membrane.
    Title: Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy.
  9. CADM4, as well as 4.1B is expressed specifically in human proximal tubules.
    Title: Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma.
  10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables vascular endothelial growth factor receptor 1 binding IEA
Inferred from Electronic Annotation
more info
  
enables vascular endothelial growth factor receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vascular endothelial growth factor receptor 2 binding IEA
Inferred from Electronic Annotation
more info
  
enables vascular endothelial growth factor receptor 2 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in homophilic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vascular endothelial growth factor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of wound healing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of wound healing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell-cell contact zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cell adhesion molecule 4
Names
TSLC1-like 2
TSLC1-like protein 2
immunoglobulin superfamily member 4C
nectin-like 4
nectin-like protein 4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145296.2 → NP_660339.1  cell adhesion molecule 4 precursor

    See identical proteins and their annotated locations for NP_660339.1

    Status: VALIDATED

    Source sequence(s)
    AC005525, AF363368
    Consensus CDS
    CCDS12627.1
    UniProtKB/Swiss-Prot
    B2R7L5, Q8NFZ8, Q9Y4A4
    UniProtKB/TrEMBL
    A0ACI8RR87
    Related
    ENSP00000222374.1, ENST00000222374.3
    Conserved Domains (5) summary
    smart00294
    Location:344 → 362
    4.1m; putative band 4.1 homologues' binding motif
    pfam13927
    Location:224 → 295
    Ig_3; Immunoglobulin domain
    cd00096
    Location:30 → 36
    Ig; Ig strand A' [structural motif]
    cd05885
    Location:121 → 220
    IgI_2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains
    cl11960
    Location:29 → 120
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43622368..43641984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026452.1 → XP_016881941.1  cell adhesion molecule 4 isoform X1

    UniProtKB/TrEMBL
    A0ACI8RR87
    Conserved Domains (5) summary
    smart00294
    Location:325 → 343
    4.1m; putative band 4.1 homologues' binding motif
    cd05885
    Location:121 → 201
    Ig2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4, also known as cell adhesion molecule 4 (CADM4))
    smart00408
    Location:218 → 279
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:212 → 289
    IG_like; Immunoglobulin like
    cl11960
    Location:10 → 101
    Ig; Immunoglobulin domain

  2. XM_005258620.3 → XP_005258677.1  cell adhesion molecule 4 isoform X2

    UniProtKB/TrEMBL
    A0ACI8RLG0, A0ACI8SGD8
    Related
    ENSP00000574214.1, ENST00000904155.2
    Conserved Domains (4) summary
    pfam13927
    Location:224 → 295
    Ig_3; Immunoglobulin domain
    cd00096
    Location:30 → 36
    Ig; Ig strand A' [structural motif]
    cd05885
    Location:121 → 220
    IgI_2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains
    cl11960
    Location:29 → 120
    Ig; Immunoglobulin domain

  3. XM_047438387.1 → XP_047294343.1  cell adhesion molecule 4 isoform X3

    UniProtKB/TrEMBL
    A0ACI8SGD8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46444027..46463643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320161.1 → XP_054176136.1  cell adhesion molecule 4 isoform X1

    UniProtKB/TrEMBL
    A0ACI8RR87

  2. XM_054320162.1 → XP_054176137.1  cell adhesion molecule 4 isoform X2

    UniProtKB/TrEMBL
    A0ACI8RLG0, A0ACI8SGD8

  3. XM_054320163.1 → XP_054176138.1  cell adhesion molecule 4 isoform X3

    UniProtKB/TrEMBL
    A0ACI8SGD8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFZ8.1 GenPept UniProtKB/Swiss-Prot:Q8NFZ8

Gene LinkOut

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