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CADM4 cell adhesion molecule 4 [ Homo sapiens (human) ]

Gene ID: 199731, updated on 22-Sep-2022

Summary

Official Symbol
CADM4provided by HGNC
Official Full Name
cell adhesion molecule 4provided by HGNC
Primary source
HGNC:HGNC:30825
See related
Ensembl:ENSG00000105767 MIM:609744; AllianceGenome:HGNC:30825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NECL4; TSLL2; IGSF4C; Necl-4; synCAM4
Summary
Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 59.7), kidney (RPKM 14.7) and 8 other tissues See more
Orthologs
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Genomic context

See CADM4 in Genome Data Viewer
Location:
19q13.31
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43622368..43641984, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46444027..46461509, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44126520..44144002, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 576 Neighboring gene zinc finger protein 428 Neighboring gene uncharacterized LOC105372411 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene plasminogen activator, urokinase receptor Neighboring gene RNA, 7SL, cytoplasmic 368, pseudogene Neighboring gene uncharacterized LOC124904724

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor receptor 1 binding IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of vascular endothelial growth factor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell-cell contact zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell adhesion molecule 4
Names
TSLC1-like 2
TSLC1-like protein 2
immunoglobulin superfamily member 4C
nectin-like 4
nectin-like protein 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145296.2NP_660339.1  cell adhesion molecule 4 precursor

    See identical proteins and their annotated locations for NP_660339.1

    Status: VALIDATED

    Source sequence(s)
    AC005525, AF363368
    Consensus CDS
    CCDS12627.1
    UniProtKB/Swiss-Prot
    Q8NFZ8, Q9Y4A4
    Related
    ENSP00000222374.1, ENST00000222374.3
    Conserved Domains (5) summary
    smart00294
    Location:344362
    4.1m; putative band 4.1 homologues' binding motif
    pfam13927
    Location:224295
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3036
    Ig; Ig strand A' [structural motif]
    cd05885
    Location:121220
    IgI_2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains
    cl11960
    Location:29120
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43622368..43641984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026452.1XP_016881941.1  cell adhesion molecule 4 isoform X1

    Conserved Domains (5) summary
    smart00294
    Location:325343
    4.1m; putative band 4.1 homologues' binding motif
    cd05885
    Location:121201
    Ig2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4, also known as cell adhesion molecule 4 (CADM4))
    smart00408
    Location:218279
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:212289
    IG_like; Immunoglobulin like
    cl11960
    Location:10101
    Ig; Immunoglobulin domain
  2. XM_005258620.3XP_005258677.1  cell adhesion molecule 4 isoform X2

    Conserved Domains (4) summary
    pfam13927
    Location:224295
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3036
    Ig; Ig strand A' [structural motif]
    cd05885
    Location:121220
    IgI_2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains
    cl11960
    Location:29120
    Ig; Immunoglobulin domain
  3. XM_047438387.1XP_047294343.1  cell adhesion molecule 4 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46444027..46461509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)