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ZNF585A zinc finger protein 585A [ Homo sapiens (human) ]

Gene ID: 199704, updated on 1-Aug-2020

Summary

Official Symbol
ZNF585Aprovided by HGNC
Official Full Name
zinc finger protein 585Aprovided by HGNC
Primary source
HGNC:HGNC:26305
See related
Ensembl:ENSG00000196967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Zfp27
Expression
Ubiquitous expression in thyroid (RPKM 3.0), testis (RPKM 2.5) and 25 other tissues See more
Orthologs

Genomic context

See ZNF585A in Genome Data Viewer
Location:
19q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (37145540..37172741, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37638340..37663643, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 829 Neighboring gene zinc finger protein 568 Neighboring gene zinc finger protein 420 Neighboring gene uncharacterized LOC105372390 Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585B Neighboring gene zinc finger protein 383

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23765, FLJ25829, FLJ31827

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288800.2NP_001275729.1  zinc finger protein 585A isoform b

    See identical proteins and their annotated locations for NP_001275729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (b).
    Source sequence(s)
    AC012309, BC063820, DA990390
    Consensus CDS
    CCDS74353.1
    UniProtKB/Swiss-Prot
    Q6P3V2
    Related
    ENSP00000292841.6, ENST00000292841.9
    Conserved Domains (6) summary
    smart00349
    Location:2785
    KRAB; krueppel associated box
    COG5048
    Location:184529
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:328347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:705728
    zf-H2C2_2; Zinc-finger double domain
  2. NM_152655.3NP_689868.1  zinc finger protein 585A isoform a

    See identical proteins and their annotated locations for NP_689868.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an additional exon in the 5' region, which results in translation intiation at a downstream AUG, compared to variant 3. The resulting isoform (a) has a shorter N-terminus, compared to isoform b. Both variants 1 and 2 encode the same isoform a.
    Source sequence(s)
    AC012309, AK074345, DA738522, DA990390
    Consensus CDS
    CCDS12499.1
    UniProtKB/Swiss-Prot
    Q6P3V2
    UniProtKB/TrEMBL
    A0A0C4DFY4
    Related
    ENSP00000349440.3, ENST00000356958.8
    Conserved Domains (4) summary
    COG5048
    Location:129474
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:273292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:650673
    zf-H2C2_2; Zinc-finger double domain
  3. NM_199126.3NP_954577.1  zinc finger protein 585A isoform a

    See identical proteins and their annotated locations for NP_954577.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon and an additional exon in the 5' region, which results in translation intiation at a downstream AUG, compared to variant 3. The resulting isoform (a) has a shorter N-terminus, compared to isoform b. Both variants 1 and 2 encode the same isoform a.
    Source sequence(s)
    AC012309, BC052956, DB454691
    Consensus CDS
    CCDS12499.1
    UniProtKB/Swiss-Prot
    Q6P3V2
    UniProtKB/TrEMBL
    A0A0C4DFY4
    Related
    ENSP00000375998.1, ENST00000392157.2
    Conserved Domains (4) summary
    COG5048
    Location:129474
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:273292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:650673
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_110152.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several exons and its transcription extends past a splice site that is used in variant 3. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AF086428, AW015367, DA990390
    Related
    ENST00000588354.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    37145540..37172741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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