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ELAVL4 ELAV like RNA binding protein 4 [ Homo sapiens (human) ]

Gene ID: 1996, updated on 15-Apr-2019

Summary

Official Symbol
ELAVL4provided by HGNC
Official Full Name
ELAV like RNA binding protein 4provided by HGNC
Primary source
HGNC:HGNC:3315
See related
Ensembl:ENSG00000162374 MIM:168360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUD; PNEM
Expression
Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.6) and 2 other tissues See more
Orthologs

Genomic context

See ELAVL4 in Genome Data Viewer
Location:
1p33-p32.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (50048014..50203786)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (50513686..50669442)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein like 4 Neighboring gene uncharacterized LOC105378708 Neighboring gene uncharacterized LOC105378709 Neighboring gene heart enhancer 18 Neighboring gene MT-ND2 pseudogene 29 Neighboring gene uncharacterized LOC107984955 Neighboring gene uncharacterized LOC105378711 Neighboring gene uncharacterized LOC105378710 Neighboring gene uncharacterized LOC105378712

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AU-rich element binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
mRNA 3'-UTR binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA processing TAS
Traceable Author Statement
more info
PubMed 
mRNA processing TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ELAV-like protein 4
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
ELAV like neuron-specific RNA binding protein 4
Hu antigen D
paraneoplastic encephalomyelitis antigen HuD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144774.2NP_001138246.1  ELAV-like protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001138246.1

    Status: VALIDATED

    Source sequence(s)
    AL592182, AY033997, BC036071, CK005107
    Consensus CDS
    CCDS44140.1
    UniProtKB/Swiss-Prot
    P26378
    Related
    ENSP00000360889.1, ENST00000371824.6
    Conserved Domains (1) summary
    TIGR01661
    Location:43365
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. NM_001144775.2NP_001138247.2  ELAV-like protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001138247.2

    Status: VALIDATED

    Source sequence(s)
    AL592182, AY033996, BC036071, BM509527
    Consensus CDS
    CCDS44139.2
    UniProtKB/Swiss-Prot
    P26378
    UniProtKB/TrEMBL
    A0A0R4J2E6
    Related
    ENSP00000349594.5, ENST00000357083.8
    Conserved Domains (1) summary
    TIGR01661
    Location:79401
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  3. NM_001144776.2NP_001138248.1  ELAV-like protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001138248.1

    Status: VALIDATED

    Source sequence(s)
    AL592182, AY033995, BC036071
    Consensus CDS
    CCDS44138.1
    UniProtKB/Swiss-Prot
    P26378
    Related
    ENSP00000360892.1, ENST00000371827.5
    Conserved Domains (1) summary
    TIGR01661
    Location:43365
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  4. NM_001144777.2NP_001138249.1  ELAV-like protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001138249.1

    Status: VALIDATED

    Source sequence(s)
    AL592182, BC036071, DC351092
    Consensus CDS
    CCDS53315.1
    UniProtKB/Swiss-Prot
    P26378
    Related
    ENSP00000399939.2, ENST00000448907.7
    Conserved Domains (1) summary
    TIGR01661
    Location:46368
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  5. NM_001294348.1NP_001281277.1  ELAV-like protein 4 isoform 6

    See identical proteins and their annotated locations for NP_001281277.1

    Status: VALIDATED

    Source sequence(s)
    AK298902, AL583843, AL592182, BC036071
    Consensus CDS
    CCDS72788.1
    UniProtKB/Swiss-Prot
    P26378
    UniProtKB/TrEMBL
    B1APY9
    Related
    ENSP00000360884.1, ENST00000371819.1
    Conserved Domains (1) summary
    TIGR01661
    Location:48370
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  6. NM_001324208.1NP_001311137.1  ELAV-like protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182, AL645730
    Conserved Domains (1) summary
    TIGR01661
    Location:46382
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  7. NM_001324209.1NP_001311138.1  ELAV-like protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Conserved Domains (1) summary
    TIGR01661
    Location:42351
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  8. NM_001324212.1NP_001311141.1  ELAV-like protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Conserved Domains (1) summary
    TIGR01661
    Location:42364
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  9. NM_001324213.1NP_001311142.1  ELAV-like protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Consensus CDS
    CCDS81321.1
    UniProtKB/TrEMBL
    B1APY8
    Related
    ENSP00000360886.1, ENST00000371821.6
    Conserved Domains (1) summary
    TIGR01661
    Location:48384
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  10. NM_001324214.1NP_001311143.1  ELAV-like protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Related
    ENSP00000498318.1, ENST00000651258.1
    Conserved Domains (1) summary
    TIGR01661
    Location:42364
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  11. NM_001324215.1NP_001311144.1  ELAV-like protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Conserved Domains (1) summary
    TIGR01661
    Location:48357
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  12. NM_001324216.1NP_001311145.1  ELAV-like protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Related
    ENSP00000498618.1, ENST00000652693.1
    Conserved Domains (1) summary
    cd12650
    Location:45118
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
  13. NM_001324217.1NP_001311146.1  ELAV-like protein 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Conserved Domains (1) summary
    cd12650
    Location:50123
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
  14. NM_021952.4NP_068771.2  ELAV-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_068771.2

    Status: VALIDATED

    Source sequence(s)
    AL592182, AY033998, BC036071, CK005107
    Consensus CDS
    CCDS553.1
    UniProtKB/Swiss-Prot
    P26378
    Related
    ENSP00000360888.4, ENST00000371823.8
    Conserved Domains (1) summary
    TIGR01661
    Location:43379
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RNA

  1. NR_136725.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    50048014..50203786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000542.1XP_016856031.1  ELAV-like protein 4 isoform X13

    Conserved Domains (1) summary
    cd12650
    Location:48121
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
  2. XM_024453827.1XP_024309595.1  ELAV-like protein 4 isoform X9

    Conserved Domains (1) summary
    TIGR01661
    Location:36358
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  3. XM_011540893.2XP_011539195.1  ELAV-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011539195.1

    Conserved Domains (4) summary
    cd12650
    Location:45122
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:294379
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:43379
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:127216
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_017000541.1XP_016856030.1  ELAV-like protein 4 isoform X12

  5. XM_017000538.1XP_016856027.1  ELAV-like protein 4 isoform X5

    Related
    ENSP00000498865.1, ENST00000651347.1
    Conserved Domains (4) summary
    cd12650
    Location:58135
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:293378
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:56378
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:140229
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_006710411.3XP_006710474.1  ELAV-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006710474.1

    Conserved Domains (4) summary
    cd12650
    Location:58135
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:307392
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:56392
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:140229
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_011540889.3XP_011539191.1  ELAV-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539191.1

    Conserved Domains (4) summary
    cd12650
    Location:81158
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:330415
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    cd12775
    Location:163252
    RRM2_HuB; RNA recognition motif 2 in vertebrate Hu-antigen B (HuB)
    TIGR01661
    Location:79415
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  8. XM_017000540.1XP_016856029.1  ELAV-like protein 4 isoform X11

  9. XM_011540890.2XP_011539192.1  ELAV-like protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011539192.1

    Conserved Domains (4) summary
    cd12650
    Location:81158
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:303388
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:79388
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:163252
    RRM_SF; RNA recognition motif (RRM) superfamily
  10. XM_024453829.1XP_024309597.1  ELAV-like protein 4 isoform X10

    Related
    ENSP00000498979.1, ENST00000650764.1
    Conserved Domains (1) summary
    TIGR01661
    Location:43352
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  11. XM_011540895.3XP_011539197.1  ELAV-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011539197.1

    Conserved Domains (4) summary
    cd12650
    Location:44121
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:293378
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:42378
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:126215
    RRM_SF; RNA recognition motif (RRM) superfamily
  12. XM_011540894.2XP_011539196.1  ELAV-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011539196.1

    Conserved Domains (4) summary
    cd12650
    Location:44121
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:293378
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:42378
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:126215
    RRM_SF; RNA recognition motif (RRM) superfamily
  13. XM_024453822.1XP_024309590.1  ELAV-like protein 4 isoform X7

    Conserved Domains (1) summary
    TIGR01661
    Location:55377
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  14. XM_024453825.1XP_024309593.1  ELAV-like protein 4 isoform X8

    Conserved Domains (1) summary
    TIGR01661
    Location:42364
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  15. XM_017000539.1XP_016856028.1  ELAV-like protein 4 isoform X9

    Related
    ENSP00000498523.1, ENST00000652274.1
    Conserved Domains (1) summary
    TIGR01661
    Location:36358
    ELAV_HUD_SF; ELAV/HuD family splicing factor
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