U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ELAVL4 ELAV like RNA binding protein 4 [ Homo sapiens (human) ]

Gene ID: 1996, updated on 5-Jul-2025
Official Symbol
ELAVL4provided by HGNC
Official Full Name
ELAV like RNA binding protein 4provided by HGNC
Primary source
HGNC:HGNC:3315
See related
Ensembl:ENSG00000162374 MIM:168360; AllianceGenome:HGNC:3315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUD; PNEM
Summary
Enables mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and pre-mRNA intronic pyrimidine-rich binding activity. Involved in 3'-UTR-mediated mRNA stabilization; RNA processing; and positive regulation of 3'-UTR-mediated mRNA stabilization. Predicted to be located in axon; cytoplasm; and dendrite. Predicted to be part of ribonucleoprotein complex. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.6) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See ELAVL4 in Genome Data Viewer
Location:
1p33-p32.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (50048055..50203772)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (49927008..50082746)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (50513727..50669444)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 4 Neighboring gene uncharacterized LOC105378708 Neighboring gene uncharacterized LOC105378709 Neighboring gene heart enhancer 18 Neighboring gene MT-ND2 pseudogene 29 Neighboring gene uncharacterized LOC105378711 Neighboring gene ELAVL4 antisense RNA 1 Neighboring gene uncharacterized LOC105378710 Neighboring gene MPRA-validated peak211 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:50774654-50774867 Neighboring gene long intergenic non-protein coding RNA 2808

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding TAS
Traceable Author Statement
more info
PubMed 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pre-mRNA intronic pyrimidine-rich binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebral cortex neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within learning IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ELAV-like protein 4
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
ELAV like neuron-specific RNA binding protein 4
Hu antigen D
paraneoplastic encephalomyelitis antigen HuD

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144774.3NP_001138246.1  ELAV-like protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001138246.1

    Status: VALIDATED

    Source sequence(s)
    AL592182, AY033997, BC036071, CK005107
    Consensus CDS
    CCDS44140.1
    UniProtKB/TrEMBL
    A0A494C015
    Related
    ENSP00000360889.2, ENST00000371824.7
    Conserved Domains (1) summary
    TIGR01661
    Location:43365
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. NM_001144775.3NP_001138247.2  ELAV-like protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001138247.2

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182, AY033996, BC036071, BM509527
    Consensus CDS
    CCDS44139.2
    UniProtKB/TrEMBL
    A0A0R4J2E6, A0A494C015
    Related
    ENSP00000349594.5, ENST00000357083.8
    Conserved Domains (1) summary
    TIGR01661
    Location:79401
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  3. NM_001144776.3NP_001138248.1  ELAV-like protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001138248.1

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182, AY033995, BC036071
    Consensus CDS
    CCDS44138.1
    UniProtKB/TrEMBL
    A0A494C015
    Related
    ENSP00000360892.1, ENST00000371827.5
    Conserved Domains (1) summary
    TIGR01661
    Location:43365
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  4. NM_001144777.3NP_001138249.1  ELAV-like protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001138249.1

    Status: VALIDATED

    Source sequence(s)
    AL592182, BC036071, DC351092
    Consensus CDS
    CCDS53315.1
    UniProtKB/TrEMBL
    A0A494C015
    Related
    ENSP00000399939.2, ENST00000448907.7
    Conserved Domains (1) summary
    TIGR01661
    Location:46368
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  5. NM_001294348.2NP_001281277.1  ELAV-like protein 4 isoform 6

    See identical proteins and their annotated locations for NP_001281277.1

    Status: VALIDATED

    Source sequence(s)
    AK298902, AL592182, BC036071
    Consensus CDS
    CCDS72788.1
    UniProtKB/TrEMBL
    A0A494C015, B1APY9
    Related
    ENSP00000360884.1, ENST00000371819.1
    Conserved Domains (1) summary
    TIGR01661
    Location:48370
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  6. NM_001324208.2NP_001311137.1  ELAV-like protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182, AL645730
    UniProtKB/TrEMBL
    A0A494C015
    Conserved Domains (1) summary
    TIGR01661
    Location:46382
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  7. NM_001324209.2NP_001311138.1  ELAV-like protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015
    Conserved Domains (1) summary
    TIGR01661
    Location:42351
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  8. NM_001324212.2NP_001311141.1  ELAV-like protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015
    Conserved Domains (1) summary
    TIGR01661
    Location:42364
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  9. NM_001324213.2NP_001311142.1  ELAV-like protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Consensus CDS
    CCDS81321.1
    UniProtKB/Swiss-Prot
    B1APY6, B1APY7, B1APY8, B7Z4G7, P26378, Q8IYD4, Q96J74, Q96J75, Q9UD24
    UniProtKB/TrEMBL
    A0A494C015
    Related
    ENSP00000360886.1, ENST00000371821.6
    Conserved Domains (1) summary
    TIGR01661
    Location:48384
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  10. NM_001324214.2NP_001311143.1  ELAV-like protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015
    Related
    ENSP00000498318.1, ENST00000651258.1
    Conserved Domains (1) summary
    TIGR01661
    Location:42364
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  11. NM_001324215.2NP_001311144.1  ELAV-like protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015
    Conserved Domains (1) summary
    TIGR01661
    Location:48357
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  12. NM_001324216.1NP_001311145.1  ELAV-like protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Consensus CDS
    CCDS90949.1
    UniProtKB/TrEMBL
    A0A494C0M6, A0A494C0Q5
    Related
    ENSP00000498618.1, ENST00000652693.1
    Conserved Domains (1) summary
    cd12650
    Location:45118
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
  13. NM_001324217.2NP_001311146.1  ELAV-like protein 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C0Q5
    Conserved Domains (1) summary
    cd12650
    Location:50123
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
  14. NM_001410787.1NP_001397716.1  ELAV-like protein 4 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Consensus CDS
    CCDS90950.1
    UniProtKB/TrEMBL
    A0A494C015, A0A494C1D9
    Related
    ENSP00000498979.1, ENST00000650764.1
  15. NM_001437726.1NP_001424655.1  ELAV-like protein 4 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015, A0A494C147
  16. NM_001438734.1NP_001425663.1  ELAV-like protein 4 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015
  17. NM_001438735.1NP_001425664.1  ELAV-like protein 4 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015
  18. NM_001438736.1NP_001425665.1  ELAV-like protein 4 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015
  19. NM_001438737.1NP_001425666.1  ELAV-like protein 4 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C015
  20. NM_001438738.1NP_001425667.1  ELAV-like protein 4 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
  21. NM_001438739.1NP_001425668.1  ELAV-like protein 4 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182, AL645730
    UniProtKB/TrEMBL
    A0A494C0Q5
  22. NM_001438740.1NP_001425669.1  ELAV-like protein 4 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    UniProtKB/TrEMBL
    A0A494C0Q5
  23. NM_021952.5NP_068771.2  ELAV-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_068771.2

    Status: VALIDATED

    Source sequence(s)
    AL592182, AY033998, BC036071, CK005107
    Consensus CDS
    CCDS553.1
    UniProtKB/TrEMBL
    A0A494C015
    Related
    ENSP00000360888.4, ENST00000371823.8
    Conserved Domains (1) summary
    TIGR01661
    Location:43379
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RNA

  1. NR_136725.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    50048055..50203772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000542.1XP_016856031.1  ELAV-like protein 4 isoform X11

    Conserved Domains (1) summary
    cd12650
    Location:48121
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
  2. XM_011540893.3XP_011539195.1  ELAV-like protein 4 isoform X4

    Conserved Domains (4) summary
    cd12650
    Location:45122
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:294379
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:43379
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:127216
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_047448337.1XP_047304293.1  ELAV-like protein 4 isoform X12

    Related
    ENST00000492299.2
  4. XM_006710411.4XP_006710474.1  ELAV-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006710474.1

    UniProtKB/TrEMBL
    A0A494C015
    Conserved Domains (1) summary
    TIGR01661
    Location:56392
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  5. XM_017000538.1XP_016856027.1  ELAV-like protein 4 isoform X5

    Related
    ENSP00000498865.1, ENST00000651347.1
    Conserved Domains (4) summary
    cd12650
    Location:58135
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:293378
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:56378
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:140229
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_017000541.2XP_016856030.1  ELAV-like protein 4 isoform X10

  7. XM_011540889.4XP_011539191.1  ELAV-like protein 4 isoform X1

    Conserved Domains (1) summary
    TIGR01661
    Location:79415
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  8. XM_011540890.3XP_011539192.1  ELAV-like protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011539192.1

    UniProtKB/TrEMBL
    A0A494C015
    Conserved Domains (1) summary
    TIGR01661
    Location:79388
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  9. XM_017000540.2XP_016856029.1  ELAV-like protein 4 isoform X9

    Conserved Domains (1) summary
    TIGR01661
    Location:79156
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  10. XM_011540895.4XP_011539197.1  ELAV-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011539197.1

    UniProtKB/TrEMBL
    A0A494C015
    Conserved Domains (1) summary
    TIGR01661
    Location:42378
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  11. XM_011540894.3XP_011539196.1  ELAV-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011539196.1

    UniProtKB/TrEMBL
    A0A494C015
    Conserved Domains (1) summary
    TIGR01661
    Location:42378
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  12. XM_024453822.2XP_024309590.1  ELAV-like protein 4 isoform X7

    Conserved Domains (1) summary
    TIGR01661
    Location:55377
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  13. XM_024453825.1XP_024309593.1  ELAV-like protein 4 isoform X8

    Conserved Domains (1) summary
    TIGR01661
    Location:42364
    ELAV_HUD_SF; ELAV/HuD family splicing factor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    49927008..50082746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334873.1XP_054190848.1  ELAV-like protein 4 isoform X11

  2. XM_054334865.1XP_054190840.1  ELAV-like protein 4 isoform X4

  3. XM_054334874.1XP_054190849.1  ELAV-like protein 4 isoform X12

  4. XM_054334872.1XP_054190847.1  ELAV-like protein 4 isoform X10

  5. XM_054334867.1XP_054190842.1  ELAV-like protein 4 isoform X5

  6. XM_054334863.1XP_054190838.1  ELAV-like protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A494C015
  7. XM_054334862.1XP_054190837.1  ELAV-like protein 4 isoform X1

  8. XM_054334864.1XP_054190839.1  ELAV-like protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A494C015
  9. XM_054334871.1XP_054190846.1  ELAV-like protein 4 isoform X9

  10. XM_054334866.1XP_054190841.1  ELAV-like protein 4 isoform X6

    UniProtKB/TrEMBL
    A0A494C015
  11. XM_054334868.1XP_054190843.1  ELAV-like protein 4 isoform X6

    UniProtKB/TrEMBL
    A0A494C015
  12. XM_054334869.1XP_054190844.1  ELAV-like protein 4 isoform X7

  13. XM_054334870.1XP_054190845.1  ELAV-like protein 4 isoform X8