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ELAVL4 ELAV like RNA binding protein 4 [ Homo sapiens (human) ]

Gene ID: 1996, updated on 1-Jun-2020

Summary

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Official Symbol
ELAVL4provided by HGNC
Official Full Name
ELAV like RNA binding protein 4provided by HGNC
Primary source
HGNC:HGNC:3315
See related
Ensembl:ENSG00000162374 MIM:168360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUD; PNEM
Expression
Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.6) and 2 other tissues See more
Orthologs
mouse all

Genomic context

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See ELAVL4 in Genome Data Viewer
Location:
1p33-p32.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (50048055..50203772)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (50513686..50669442)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein like 4 Neighboring gene uncharacterized LOC105378708 Neighboring gene uncharacterized LOC105378709 Neighboring gene heart enhancer 18 Neighboring gene MT-ND2 pseudogene 29 Neighboring gene uncharacterized LOC105378711 Neighboring gene ELAVL4 antisense RNA 1 Neighboring gene uncharacterized LOC105378710 Neighboring gene long intergenic non-protein coding RNA 2808

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis. Wang F, et al. Anticancer Res, 2017 Aug. PMID 28739747
  2. HuD promotes progression of oral squamous cell carcinoma. Sasahira T, et al. Pathobiology, 2014. PMID 25278027
  3. Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR. Schulz S, et al. Cell Signal, 2013 Dec. PMID 23978401
  4. Reduced expression of ELAVL4 in male meningioma patients. Stawski R, et al. Brain Tumor Pathol, 2013 Jul. PMID 22965691
  5. Identification of ELAVL4 as a modulator of radiation sensitivity in A549 non-small cell lung cancer cells. Choi KJ, et al. Oncol Rep, 2011 Jul. PMID 21491091

See all (58) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors.
    Title: Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27<sup>Kip1</sup> levels and poor prognosis.
  2. the relative expression levels of Kv11.1 C-terminal isoforms are regulated by the RNA-binding HuR and HuD proteins
    Title: Regulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD.
  3. N-myc levels appear to be modulated by the antagonistic interactions of both miR-17, as a negative regulator, and HuD, as a positive regulator in N-myc-amplified neuroblastoma cells.
    Title: Reciprocal antagonistic regulation of N-myc mRNA by miR‑17 and the neuronal-specific RNA-binding protein HuD.
  4. The high titres of HuD in SCLC patients and preferable consistency suggested that HuD may serve as a potential diagnostic criterium for SCLC and may serve as a marker of disease progression.
    Title: Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis.
  5. HuD binds to the APP and BACE1 3' UTRs and increases APP and BACE1 levels.
    Title: HuD regulates coding and noncoding RNA to induce APP→Aβ processing.
  6. study showed HuD is associated with histological grade, iffuse invasion and nodal metastasis in oral squamous cell carcinoma; it regulates expression of VEGF-A, VEGF-D, MMP-2 and MMP-9
    Title: HuD promotes progression of oral squamous cell carcinoma.
  7. Phosphomimetic mutation at position Ser 221 increased nuclear HUD export.
    Title: Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR.
  8. Alzheimer's disease brain tissues with elevated neuroserpin protein also showed increased expression of THRbeta1 and HuD
    Title: Neuroserpin up-regulation in the Alzheimer's disease brain is associated with elevated thyroid hormone receptor-β1 and HuD expression.
  9. It can be involved in the pathogenesis of meningiomas in male patients.
    Title: Reduced expression of ELAVL4 in male meningioma patients.
  10. found that p97 and its cofactor, UBXD8, destabilize p21, MKP-1, and SIRT1, three established mRNA targets of the RNA-binding protein HuR, by promoting release of HuR from mRNA
    Title: The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
 PubMed 
mRNA 3'-UTR binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
  
mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
  
dendrite IEA
Inferred from Electronic Annotation
more info
  
growth cone IEA
Inferred from Electronic Annotation
more info
  
perikaryon IEA
Inferred from Electronic Annotation
more info
  
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ELAV-like protein 4
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
ELAV like neuron-specific RNA binding protein 4
Hu antigen D
paraneoplastic encephalomyelitis antigen HuD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144774.3 → NP_001138246.1  ELAV-like protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001138246.1

    Status: VALIDATED

    Source sequence(s)
    AL592182, AY033997, BC036071, CK005107
    Consensus CDS
    CCDS44140.1
    UniProtKB/Swiss-Prot
    P26378
    Related
    ENSP00000360889.1, ENST00000371824.6
    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 365
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. NM_001144775.3 → NP_001138247.2  ELAV-like protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001138247.2

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182, AY033996, BC036071, BM509527
    Consensus CDS
    CCDS44139.2
    UniProtKB/Swiss-Prot
    P26378
    UniProtKB/TrEMBL
    A0A0R4J2E6
    Related
    ENSP00000349594.5, ENST00000357083.8
    Conserved Domains (1) summary
    TIGR01661
    Location:79 → 401
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. NM_001144776.3 → NP_001138248.1  ELAV-like protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001138248.1

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182, AY033995, BC036071
    Consensus CDS
    CCDS44138.1
    UniProtKB/Swiss-Prot
    P26378
    Related
    ENSP00000360892.1, ENST00000371827.5
    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 365
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  4. NM_001144777.3 → NP_001138249.1  ELAV-like protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001138249.1

    Status: VALIDATED

    Source sequence(s)
    AL592182, BC036071, DC351092
    Consensus CDS
    CCDS53315.1
    UniProtKB/Swiss-Prot
    P26378
    Related
    ENSP00000399939.2, ENST00000448907.7
    Conserved Domains (1) summary
    TIGR01661
    Location:46 → 368
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  5. NM_001294348.2 → NP_001281277.1  ELAV-like protein 4 isoform 6

    See identical proteins and their annotated locations for NP_001281277.1

    Status: VALIDATED

    Source sequence(s)
    AK298902, AL592182, BC036071
    Consensus CDS
    CCDS72788.1
    UniProtKB/Swiss-Prot
    P26378
    UniProtKB/TrEMBL
    B1APY9
    Related
    ENSP00000360884.1, ENST00000371819.1
    Conserved Domains (1) summary
    TIGR01661
    Location:48 → 370
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  6. NM_001324208.2 → NP_001311137.1  ELAV-like protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182, AL645730
    Conserved Domains (1) summary
    TIGR01661
    Location:46 → 382
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  7. NM_001324209.2 → NP_001311138.1  ELAV-like protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Conserved Domains (1) summary
    TIGR01661
    Location:42 → 351
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  8. NM_001324212.2 → NP_001311141.1  ELAV-like protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Conserved Domains (1) summary
    TIGR01661
    Location:42 → 364
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  9. NM_001324213.2 → NP_001311142.1  ELAV-like protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Consensus CDS
    CCDS81321.1
    UniProtKB/TrEMBL
    B1APY8
    Related
    ENSP00000360886.1, ENST00000371821.6
    Conserved Domains (1) summary
    TIGR01661
    Location:48 → 384
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  10. NM_001324214.2 → NP_001311143.1  ELAV-like protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Related
    ENSP00000498318.1, ENST00000651258.1
    Conserved Domains (1) summary
    TIGR01661
    Location:42 → 364
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  11. NM_001324215.2 → NP_001311144.1  ELAV-like protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Conserved Domains (1) summary
    TIGR01661
    Location:48 → 357
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  12. NM_001324216.1 → NP_001311145.1  ELAV-like protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Related
    ENSP00000498618.1, ENST00000652693.1
    Conserved Domains (1) summary
    cd12650
    Location:45 → 118
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

  13. NM_001324217.2 → NP_001311146.1  ELAV-like protein 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182
    Conserved Domains (1) summary
    cd12650
    Location:50 → 123
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

  14. NM_021952.5 → NP_068771.2  ELAV-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_068771.2

    Status: VALIDATED

    Source sequence(s)
    AL592182, AY033998, BC036071, CK005107
    Consensus CDS
    CCDS553.1
    UniProtKB/Swiss-Prot
    P26378
    Related
    ENSP00000360888.4, ENST00000371823.8
    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 379
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RNA

  1. NR_136725.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL583843, AL592182

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    50048055..50203772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000542.1 → XP_016856031.1  ELAV-like protein 4 isoform X13

    Related
    ENST00000492299.2
    Conserved Domains (1) summary
    cd12650
    Location:48 → 121
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

  2. XM_024453827.1 → XP_024309595.1  ELAV-like protein 4 isoform X9

    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. XM_011540893.2 → XP_011539195.1  ELAV-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011539195.1

    Conserved Domains (4) summary
    cd12650
    Location:45 → 122
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:294 → 379
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:43 → 379
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:127 → 216
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_017000541.1 → XP_016856030.1  ELAV-like protein 4 isoform X12

  5. XM_017000538.1 → XP_016856027.1  ELAV-like protein 4 isoform X5

    Related
    ENSP00000498865.1, ENST00000651347.1
    Conserved Domains (4) summary
    cd12650
    Location:58 → 135
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:293 → 378
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:56 → 378
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:140 → 229
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_006710411.3 → XP_006710474.1  ELAV-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006710474.1

    Conserved Domains (4) summary
    cd12650
    Location:58 → 135
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:307 → 392
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:56 → 392
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:140 → 229
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_011540889.3 → XP_011539191.1  ELAV-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539191.1

    Conserved Domains (4) summary
    cd12650
    Location:81 → 158
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:330 → 415
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    cd12775
    Location:163 → 252
    RRM2_HuB; RNA recognition motif 2 in vertebrate Hu-antigen B (HuB)
    TIGR01661
    Location:79 → 415
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  8. XM_017000540.1 → XP_016856029.1  ELAV-like protein 4 isoform X11

  9. XM_011540890.2 → XP_011539192.1  ELAV-like protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011539192.1

    Conserved Domains (4) summary
    cd12650
    Location:81 → 158
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12656
    Location:303 → 388
    RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
    TIGR01661
    Location:79 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:163 → 252
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. XM_024453829.1 → XP_024309597.1  ELAV-like protein 4 isoform X10

    Related
    ENSP00000498979.1, ENST00000650764.1
    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 352
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  11. XM_011540895.3 → XP_011539197.1  ELAV-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011539197.1

    Conserved Domains (1) summary
    TIGR01661
    Location:42 → 378
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  12. XM_011540894.2 → XP_011539196.1  ELAV-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011539196.1

    Conserved Domains (1) summary
    TIGR01661
    Location:42 → 378
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  13. XM_024453822.1 → XP_024309590.1  ELAV-like protein 4 isoform X7

    Conserved Domains (1) summary
    TIGR01661
    Location:55 → 377
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  14. XM_024453825.1 → XP_024309593.1  ELAV-like protein 4 isoform X8

    Conserved Domains (1) summary
    TIGR01661
    Location:42 → 364
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  15. XM_017000539.1 → XP_016856028.1  ELAV-like protein 4 isoform X9

    Related
    ENSP00000498523.1, ENST00000652274.1
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26378.3 GenPept UniProtKB/Swiss-Prot:P26378

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