ELAVL4 ELAV like RNA binding protein 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ELAVL4provided by HGNC
Official Full Name: ELAV like RNA binding protein 4provided by HGNC
Primary source: HGNC:HGNC:3315
See related: Ensembl:ENSG00000162374 MIM:168360; AllianceGenome:HGNC:3315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HUD; PNEM
Summary: Enables mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and pre-mRNA intronic pyrimidine-rich binding activity. Involved in 3'-UTR-mediated mRNA stabilization; RNA processing; and positive regulation of 3'-UTR-mediated mRNA stabilization. Predicted to be located in axon; cytoplasm; and dendrite. Predicted to be part of polysomal ribosome. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.6) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p33-p32.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (50048055..50203772)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (49927008..50082746)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (50513727..50669444)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.
Title: RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Title: ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex.
Title: HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex.
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
Title: ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
HuB and HuD repress telomerase activity by dissociating HuR from TERC.
Title: HuB and HuD repress telomerase activity by dissociating HuR from TERC.
pathological mutations in FUS trigger an aberrant crosstalk with ELAVL4 with implications for Amyotrophic lateral sclerosis.
Title: Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.
HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors.
Title: Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27<sup>Kip1</sup> levels and poor prognosis.
the relative expression levels of Kv11.1 C-terminal isoforms are regulated by the RNA-binding HuR and HuD proteins
Title: Regulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD.
N-myc levels appear to be modulated by the antagonistic interactions of both miR-17, as a negative regulator, and HuD, as a positive regulator in N-myc-amplified neuroblastoma cells.
Title: Reciprocal antagonistic regulation of N-myc mRNA by miR‑17 and the neuronal-specific RNA-binding protein HuD.
The high titres of HuD in SCLC patients and preferable consistency suggested that HuD may serve as a potential diagnostic criterium for SCLC and may serve as a marker of disease progression.
Title: Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-83296 (e-PCR)
- UniSTS:101173

RH122329 (e-PCR)
- UniSTS:137850

D1S2299E (e-PCR)
- UniSTS:153733

AL009829 (e-PCR)
- UniSTS:61831

SHGC-81055 (e-PCR)
- UniSTS:103572

AL009479 (e-PCR)
- UniSTS:34209

D1S1559 (e-PCR)
- UniSTS:72102

SHGC-74804 (e-PCR)
- UniSTS:29635

ELAVL4__7579 (e-PCR)
- UniSTS:466146

Homology

Homologs of the ELAVL4 gene: The ELAVL4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, and frog.
Orthologs from Annotation Pipeline: 446 organisms have orthologs with human gene ELAVL4
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(A) binding	IDA Inferred from Direct Assay more info	PubMed
enables pre-mRNA intronic pyrimidine-rich binding	IDA Inferred from Direct Assay more info	PubMed
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in aging	IEA Inferred from Electronic Annotation more info
involved_in associative learning	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendrite development	IEA Inferred from Electronic Annotation more info
involved_in regeneration	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation at postsynapse	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in polysomal ribosome	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ELAV-like protein 4

Names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV like neuron-specific RNA binding protein 4; Hu antigen D; paraneoplastic encephalomyelitis antigen HuD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001144774.3 → NP_001138246.1 ELAV-like protein 4 isoform 2

See identical proteins and their annotated locations for NP_001138246.1

Status: VALIDATED

Source sequence(s)

AL592182, AY033997, BC036071, CK005107

Consensus CDS

CCDS44140.1

UniProtKB/Swiss-Prot

P26378

Related

ENSP00000360889.2, ENST00000371824.7

Conserved Domains (1) summary

TIGR01661
Location:43 → 365

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001144775.3 → NP_001138247.2 ELAV-like protein 4 isoform 3

See identical proteins and their annotated locations for NP_001138247.2

Status: VALIDATED

Source sequence(s)

AL583843, AL592182, AY033996, BC036071, BM509527

Consensus CDS

CCDS44139.2

UniProtKB/Swiss-Prot

P26378

UniProtKB/TrEMBL

A0A0R4J2E6

Related

ENSP00000349594.5, ENST00000357083.8

Conserved Domains (1) summary

TIGR01661
Location:79 → 401

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001144776.3 → NP_001138248.1 ELAV-like protein 4 isoform 4

See identical proteins and their annotated locations for NP_001138248.1

Status: VALIDATED

Source sequence(s)

AL583843, AL592182, AY033995, BC036071

Consensus CDS

CCDS44138.1

UniProtKB/Swiss-Prot

P26378

Related

ENSP00000360892.1, ENST00000371827.5

Conserved Domains (1) summary

TIGR01661
Location:43 → 365

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001144777.3 → NP_001138249.1 ELAV-like protein 4 isoform 5

See identical proteins and their annotated locations for NP_001138249.1

Status: VALIDATED

Source sequence(s)

AL592182, BC036071, DC351092

Consensus CDS

CCDS53315.1

UniProtKB/Swiss-Prot

P26378

Related

ENSP00000399939.2, ENST00000448907.7

Conserved Domains (1) summary

TIGR01661
Location:46 → 368

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001294348.2 → NP_001281277.1 ELAV-like protein 4 isoform 6

See identical proteins and their annotated locations for NP_001281277.1

Status: VALIDATED

Source sequence(s)

AK298902, AL592182, BC036071

Consensus CDS

CCDS72788.1

UniProtKB/Swiss-Prot

P26378

UniProtKB/TrEMBL

B1APY9

Related

ENSP00000360884.1, ENST00000371819.1

Conserved Domains (1) summary

TIGR01661
Location:48 → 370

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001324208.2 → NP_001311137.1 ELAV-like protein 4 isoform 7

Status: VALIDATED

Source sequence(s)

AL583843, AL592182, AL645730

Conserved Domains (1) summary

TIGR01661
Location:46 → 382

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001324209.2 → NP_001311138.1 ELAV-like protein 4 isoform 8

Status: VALIDATED

Source sequence(s)

AL583843, AL592182

Conserved Domains (1) summary

TIGR01661
Location:42 → 351

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001324212.2 → NP_001311141.1 ELAV-like protein 4 isoform 13

Status: VALIDATED

Source sequence(s)

AL583843, AL592182

Conserved Domains (1) summary

TIGR01661
Location:42 → 364

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001324213.2 → NP_001311142.1 ELAV-like protein 4 isoform 9

Status: VALIDATED

Source sequence(s)

AL583843, AL592182

Consensus CDS

CCDS81321.1

UniProtKB/Swiss-Prot

Q9UD24

UniProtKB/TrEMBL

B1APY8

Related

ENSP00000360886.1, ENST00000371821.6

Conserved Domains (1) summary

TIGR01661
Location:48 → 384

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001324214.2 → NP_001311143.1 ELAV-like protein 4 isoform 13

Status: VALIDATED

Source sequence(s)

AL583843, AL592182

Related

ENSP00000498318.1, ENST00000651258.1

Conserved Domains (1) summary

TIGR01661
Location:42 → 364

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001324215.2 → NP_001311144.1 ELAV-like protein 4 isoform 10

Status: VALIDATED

Source sequence(s)

AL583843, AL592182

Conserved Domains (1) summary

TIGR01661
Location:48 → 357

ELAV_HUD_SF; ELAV/HuD family splicing factor
NM_001324216.1 → NP_001311145.1 ELAV-like protein 4 isoform 11

Status: VALIDATED

Source sequence(s)

AL583843, AL592182

UniProtKB/TrEMBL

A0A494C0M6

Related

ENSP00000498618.1, ENST00000652693.1

Conserved Domains (1) summary

cd12650
Location:45 → 118

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
NM_001324217.2 → NP_001311146.1 ELAV-like protein 4 isoform 12

Status: VALIDATED

Source sequence(s)

AL583843, AL592182

Conserved Domains (1) summary

cd12650
Location:50 → 123

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
NM_001410787.1 → NP_001397716.1 ELAV-like protein 4 isoform 14

Status: VALIDATED

Source sequence(s)

AL583843, AL592182
NM_021952.5 → NP_068771.2 ELAV-like protein 4 isoform 1

See identical proteins and their annotated locations for NP_068771.2

Status: VALIDATED

Source sequence(s)

AL592182, AY033998, BC036071, CK005107

Consensus CDS

CCDS553.1

UniProtKB/Swiss-Prot

P26378

Related

ENSP00000360888.4, ENST00000371823.8

Conserved Domains (1) summary

TIGR01661
Location:43 → 379

ELAV_HUD_SF; ELAV/HuD family splicing factor

RNA

NR_136725.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL583843, AL592182

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

50048055..50203772

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017000542.1 → XP_016856031.1 ELAV-like protein 4 isoform X12

Conserved Domains (1) summary

cd12650
Location:48 → 121

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
XM_011540893.3 → XP_011539195.1 ELAV-like protein 4 isoform X4

See identical proteins and their annotated locations for XP_011539195.1

Conserved Domains (4) summary

cd12650
Location:45 → 122

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

cd12656
Location:294 → 379

RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)

TIGR01661
Location:43 → 379

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:127 → 216

RRM_SF; RNA recognition motif (RRM) superfamily
XM_047448337.1 → XP_047304293.1 ELAV-like protein 4 isoform X13

Related

ENST00000492299.2
XM_006710411.4 → XP_006710474.1 ELAV-like protein 4 isoform X2

See identical proteins and their annotated locations for XP_006710474.1

Conserved Domains (1) summary

TIGR01661
Location:56 → 392

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_017000538.1 → XP_016856027.1 ELAV-like protein 4 isoform X5

UniProtKB/TrEMBL

A0A494C147

Related

ENSP00000498865.1, ENST00000651347.1

Conserved Domains (4) summary

cd12650
Location:58 → 135

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

cd12656
Location:293 → 378

RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)

TIGR01661
Location:56 → 378

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:140 → 229

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017000541.2 → XP_016856030.1 ELAV-like protein 4 isoform X11
XM_011540889.4 → XP_011539191.1 ELAV-like protein 4 isoform X1

See identical proteins and their annotated locations for XP_011539191.1

Conserved Domains (1) summary

TIGR01661
Location:79 → 415

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_011540890.3 → XP_011539192.1 ELAV-like protein 4 isoform X3

See identical proteins and their annotated locations for XP_011539192.1

Conserved Domains (1) summary

TIGR01661
Location:79 → 388

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_017000540.2 → XP_016856029.1 ELAV-like protein 4 isoform X10

Conserved Domains (1) summary

TIGR01661
Location:79 → 156

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_011540895.4 → XP_011539197.1 ELAV-like protein 4 isoform X6

See identical proteins and their annotated locations for XP_011539197.1

Conserved Domains (1) summary

TIGR01661
Location:42 → 378

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_024453829.1 → XP_024309597.1 ELAV-like protein 4 isoform X9

UniProtKB/TrEMBL

A0A494C1D9

Related

ENSP00000498979.1, ENST00000650764.1

Conserved Domains (1) summary

TIGR01661
Location:43 → 352

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_011540894.3 → XP_011539196.1 ELAV-like protein 4 isoform X6

See identical proteins and their annotated locations for XP_011539196.1

Conserved Domains (1) summary

TIGR01661
Location:42 → 378

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_024453822.2 → XP_024309590.1 ELAV-like protein 4 isoform X7

Conserved Domains (1) summary

TIGR01661
Location:55 → 377

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_024453825.1 → XP_024309593.1 ELAV-like protein 4 isoform X8

Conserved Domains (1) summary

TIGR01661
Location:42 → 364

ELAV_HUD_SF; ELAV/HuD family splicing factor