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ELAVL3 ELAV like RNA binding protein 3 [ Homo sapiens (human) ]

Gene ID: 1995, updated on 7-Dec-2018

Summary

Official Symbol
ELAVL3provided by HGNC
Official Full Name
ELAV like RNA binding protein 3provided by HGNC
Primary source
HGNC:HGNC:3314
See related
Ensembl:ENSG00000196361 MIM:603458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUC; HUCL; PLE21
Summary
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 22.9) See more
Orthologs

Genomic context

See ELAVL3 in Genome Data Viewer
Location:
19p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (11451326..11481046, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11562143..11591806, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator like 3 Neighboring gene coiled-coil domain containing 151 Neighboring gene protein kinase C substrate 80K-H Neighboring gene zinc finger protein 653 Neighboring gene microRNA 7974 Neighboring gene ECSIT signalling integrator Neighboring gene RNA, 7SL, cytoplasmic 833, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20653, DKFZp547J036

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AU-rich element binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ELAV-like protein 3
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
ELAV like neuron-specific RNA binding protein 3
Hu antigen C
hu-antigen C
paraneoplastic cerebellar degeneration-associated antigen
paraneoplastic limbic encephalitis antigen 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420.4NP_001411.2  ELAV-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001411.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC008481, AI199100, AL512714, BC014144, BI117592, L26405
    Consensus CDS
    CCDS32912.1
    UniProtKB/Swiss-Prot
    Q14576
    Related
    ENSP00000352162.1, ENST00000359227.7
    Conserved Domains (1) summary
    TIGR01661
    Location:36366
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. NM_032281.2NP_115657.2  ELAV-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_115657.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, as compared to variant 1. It encodes isoform 2 which lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AI199100, AL512714, AY036909, BC014144, BI117592, L26405
    Consensus CDS
    CCDS45978.1
    UniProtKB/Swiss-Prot
    Q14576
    Related
    ENSP00000390878.1, ENST00000438662.6
    Conserved Domains (1) summary
    TIGR01661
    Location:36359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    11451326..11481046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451413.1XP_024307181.1  ELAV-like protein 3 isoform X5

    Conserved Domains (1) summary
    TIGR01661
    Location:35358
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. XM_011527778.3XP_011526080.1  ELAV-like protein 3 isoform X4

    See identical proteins and their annotated locations for XP_011526080.1

    Conserved Domains (1) summary
    TIGR01661
    Location:35365
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  3. XM_024451411.1XP_024307179.1  ELAV-like protein 3 isoform X2

    Conserved Domains (1) summary
    cl25887
    Location:35422
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  4. XM_024451412.1XP_024307180.1  ELAV-like protein 3 isoform X3

    Conserved Domains (1) summary
    cl25887
    Location:36416
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  5. XM_024451410.1XP_024307178.1  ELAV-like protein 3 isoform X1

    Conserved Domains (1) summary
    cl25887
    Location:36423
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
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