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Rpl22 ribosomal protein L22 [ Mus musculus (house mouse) ]

Gene ID: 19934, updated on 9-May-2024

Summary

Official Symbol
Rpl22provided by MGI
Official Full Name
ribosomal protein L22provided by MGI
Primary source
MGI:MGI:99262
See related
Ensembl:ENSMUSG00000028936 AllianceGenome:MGI:99262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700038K18Rik
Summary
Enables heparin binding activity and translation regulator activity. Involved in regulation of translation at presynapse, modulating synaptic transmission. Acts upstream of or within alpha-beta T cell differentiation. Located in glutamatergic synapse; presynapse; and ribosome. Orthologous to human RPL22 (ribosomal protein L22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 82.1), bladder adult (RPKM 62.7) and 25 other tissues See more
Orthologs
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Genomic context

Location:
4 E2; 4 83.03 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152408893..152418539)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152324436..152334082)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4736 Neighboring gene G protein-coupled receptor 153 Neighboring gene STARR-positive B cell enhancer ABC_E3558 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ring finger protein 207 Neighboring gene STARR-positive B cell enhancer ABC_E846 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, beta member 2 Neighboring gene predicted gene 16333

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation at presynapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translation at presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in ribosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
large ribosomal subunit protein eL22
Names
60S ribosomal protein L22
heparin-binding protein HBp15
NP_001264042.1
NP_001264043.1
NP_033105.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277113.1NP_001264042.1  large ribosomal subunit protein eL22 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Conserved Domains (1) summary
    pfam01776
    Location:39142
    Ribosomal_L22e; Ribosomal L22e protein family
  2. NM_001277114.2NP_001264043.1  large ribosomal subunit protein eL22 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Conserved Domains (1) summary
    pfam01776
    Location:1680
    Ribosomal_L22e; Ribosomal L22e protein family
  3. NM_009079.4NP_033105.1  large ribosomal subunit protein eL22 isoform a

    See identical proteins and their annotated locations for NP_033105.1

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS18999.1
    UniProtKB/Swiss-Prot
    P67984
    UniProtKB/TrEMBL
    Q4VAG4
    Related
    ENSMUSP00000118787.2, ENSMUST00000139685.8
    Conserved Domains (1) summary
    pfam01776
    Location:21119
    Ribosomal_L22e; Ribosomal L22e protein family

RNA

  1. NR_102291.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611985
  2. NR_102292.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611985

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152408893..152418539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)