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Rpl10a ribosomal protein L10A [ Mus musculus (house mouse) ]

Gene ID: 19896, updated on 5-Jan-2023

Summary

Official Symbol
Rpl10aprovided by MGI
Official Full Name
ribosomal protein L10Aprovided by MGI
Primary source
MGI:MGI:1343877
See related
Ensembl:ENSMUSG00000037805 AllianceGenome:MGI:1343877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nedd6; CsA-19
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and maturation of LSU-rRNA. Located in synapse. Is expressed in several structures, including cerebral cortex; heart; immune system; liver; and lung. Orthologous to human RPL10A (ribosomal protein L10a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 583.9), CNS E11.5 (RPKM 479.8) and 28 other tissues See more
Orthologs
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Genomic context

See Rpl10a in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28547445..28550007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28328471..28331033)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene peroxisome proliferator activator receptor delta Neighboring gene RIKEN cDNA 1810013A23 gene Neighboring gene Fanconi anemia, complementation group E Neighboring gene TEA domain family member 3 Neighboring gene tubby like protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation ISO
Inferred from Sequence Orthology
more info
 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in polysomal ribosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L10a
Names
NEDD-6
neural precursor cell expressed developmentally down-regulated protein 6
NP_001344557.1
NP_035417.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357628.2NP_001344557.1  60S ribosomal protein L10a isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025652
    UniProtKB/TrEMBL
    A0A8C6I7N2, Q99JL6
    Related
    ENSMUST00000150103.3
    Conserved Domains (1) summary
    cl00322
    Location:23133
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...
  2. NM_011287.3NP_035417.2  60S ribosomal protein L10a isoform 1

    See identical proteins and their annotated locations for NP_035417.2

    Status: VALIDATED

    Source sequence(s)
    CT025652
    Consensus CDS
    CCDS28576.1
    UniProtKB/TrEMBL
    A0A6P5RA35, Q5XJF6
    Related
    ENSMUSP00000048469.9, ENSMUST00000042334.16
    Conserved Domains (1) summary
    cl00322
    Location:2217
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28547445..28550007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)