U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rora RAR-related orphan receptor alpha [ Mus musculus (house mouse) ]

Gene ID: 19883, updated on 26-Sep-2023

Summary

Go to the top of the page Help
Official Symbol
Roraprovided by MGI
Official Full Name
RAR-related orphan receptor alphaprovided by MGI
Primary source
MGI:MGI:104661
See related
Ensembl:ENSMUSG00000032238 AllianceGenome:MGI:104661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sg; ROR1; ROR2; ROR3; Nr1f1; nmf267; tmgc26; staggerer; 9530021D13Rik
Summary
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Broad expression in cerebellum adult (RPKM 8.5), cortex adult (RPKM 3.0) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rora in Genome Data Viewer
Location:
9 C; 9 37.45 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (68560627..69295528)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (68653404..69388246)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930502A04 gene Neighboring gene predicted gene, 31141 Neighboring gene predicted gene, 31325 Neighboring gene RIKEN cDNA 9530091C08 gene Neighboring gene predicted gene, 53536 Neighboring gene predicted gene, 53537 Neighboring gene predicted gene, 31262 Neighboring gene predicted gene, 46153 Neighboring gene predicted gene 15511 Neighboring gene predicted gene 7802 Neighboring gene interactor of little elongation complex ELL subunit 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The suppressive functions of Rora in B lineage cell proliferation and BCR/ABL1-induced B-ALL pathogenesis. Li N, et al. Int J Biol Sci, 2022. PMID 35414788, Free PMC Article
  2. Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring. Xiao L, et al. BMC Neurosci, 2022 Feb 14. PMID 35164690, Free PMC Article
  3. Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase. Yu H, et al. Commun Biol, 2022 Jan 13. PMID 35027651, Free PMC Article
  4. RORα contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis. Kim JY, et al. Am J Physiol Endocrinol Metab, 2022 Feb 1. PMID 34894722
  5. Mapping Rora expression in resting and activated CD4+ T cells. Haim-Vilmovsky L, et al. PLoS One, 2021. PMID 34003838, Free PMC Article

See all (388) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORalpha in nucleus pulposus cells.
    Title: MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells.
  2. Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring.
    Title: Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring.
  3. RORalpha is critical for mTORC1 activity in T cell-mediated colitis.
    Title: RORα is critical for mTORC1 activity in T cell-mediated colitis.
  4. The nuclear receptor RORalpha preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy.
    Title: The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy.
  5. RORalpha contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis.
    Title: RORα contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis.
  6. Inhibition of nuclear receptor RORalpha attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway.
    Title: Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway.
  7. Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORalpha) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock.
    Title: Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORα) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock.
  8. Loss of retinoic acid receptor-related receptor alpha (Roralpha) promotes the progression of UV-induced cSCC.
    Title: Loss of retinoic acid receptor-related receptor alpha (Rorα) promotes the progression of UV-induced cSCC.
  9. RORalpha regulates hepatic lipolysis by inducing transcriptional expression of PNPLA3 in mice.
    Title: RORα regulates hepatic lipolysis by inducing transcriptional expression of PNPLA3 in mice.
  10. lncRNA-SNHG14 Promotes Atherosclerosis by Regulating RORalpha Expression through Sponge miR-19a-3p.
    Title: lncRNA-SNHG14 Promotes Atherosclerosis by Regulating RORα Expression through Sponge miR-19a-3p.
Submit: New GeneRIF Correction See all GeneRIFs (103)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ligand-activated transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables oxysterol binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables oxysterol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cGMP metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to sterol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebellar granule cell precursor proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of steroid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear receptor ROR-alpha
Names
RAR-related orphan receptor A
nuclear receptor RZR-alpha
nuclear receptor subfamily 1 group F member 1
retinoid-related orphan receptor-alpha

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289916.1 → NP_001276845.1  nuclear receptor ROR-alpha isoform 2

    See identical proteins and their annotated locations for NP_001276845.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK155827, CT009708, Y08640
    Consensus CDS
    CCDS72268.1
    UniProtKB/Swiss-Prot
    P51448
    UniProtKB/TrEMBL
    Q3U1P4
    Related
    ENSMUSP00000109254.3, ENSMUST00000113624.3
    Conserved Domains (2) summary
    cd06939
    Location:216 → 455
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:10 → 104
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

  2. NM_001289917.1 → NP_001276846.1  nuclear receptor ROR-alpha isoform 3

    See identical proteins and their annotated locations for NP_001276846.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and shares only the first exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC155931, AK086033
    UniProtKB/TrEMBL
    Q8C3F5
    Related
    ENSMUST00000140351.8

  3. NM_013646.2 → NP_038674.1  nuclear receptor ROR-alpha isoform 1

    See identical proteins and their annotated locations for NP_038674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK086033, CT009708, U53228
    Consensus CDS
    CCDS23314.1
    UniProtKB/Swiss-Prot
    P51448, P70283, P97741, P97773, Q923G1
    UniProtKB/TrEMBL
    Q8C3F5
    Related
    ENSMUSP00000034766.7, ENSMUST00000034766.14
    Conserved Domains (2) summary
    cd06939
    Location:272 → 511
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:66 → 160
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    68560627..69295528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154733.1 → XP_036010626.1  nuclear receptor ROR-alpha isoform X1

    Conserved Domains (2) summary
    cd06939
    Location:272 → 510
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:66 → 160
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

  2. XM_030244146.2 → XP_030100006.1  nuclear receptor ROR-alpha isoform X6

    UniProtKB/TrEMBL
    Q8BRL5
    Conserved Domains (2) summary
    cd06939
    Location:135 → 374
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cl02596
    Location:1 → 23
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  3. XM_011242682.4 → XP_011240984.1  nuclear receptor ROR-alpha isoform X8

  4. XM_006510880.2 → XP_006510943.1  nuclear receptor ROR-alpha isoform X5

    Conserved Domains (2) summary
    cd06939
    Location:208 → 447
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:2 → 96
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

  5. XM_006510878.4 → XP_006510941.1  nuclear receptor ROR-alpha isoform X3

    Conserved Domains (2) summary
    cd06939
    Location:224 → 463
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:18 → 112
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

  6. XM_036154734.1 → XP_036010627.1  nuclear receptor ROR-alpha isoform X4

    Conserved Domains (2) summary
    cd06939
    Location:216 → 454
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:10 → 104
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

  7. XM_030244147.2 → XP_030100007.1  nuclear receptor ROR-alpha isoform X6

    UniProtKB/TrEMBL
    Q8BRL5
    Conserved Domains (2) summary
    cd06939
    Location:135 → 374
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cl02596
    Location:1 → 23
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  8. XM_036154737.1 → XP_036010630.1  nuclear receptor ROR-alpha isoform X7

    UniProtKB/TrEMBL
    Q8BRL5
    Conserved Domains (2) summary
    cd06939
    Location:135 → 373
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cl02596
    Location:1 → 23
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  9. XM_036154736.1 → XP_036010629.1  nuclear receptor ROR-alpha isoform X6

    UniProtKB/TrEMBL
    Q8BRL5
    Conserved Domains (2) summary
    cd06939
    Location:135 → 374
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cl02596
    Location:1 → 23
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  10. XM_006510877.5 → XP_006510940.1  nuclear receptor ROR-alpha isoform X2

    Conserved Domains (2) summary
    cd06939
    Location:269 → 508
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:63 → 157
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

RNA

  1. XR_004935350.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51448.1 GenPept UniProtKB/Swiss-Prot:P51448

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous