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Rnf7 ring finger protein 7 [ Mus musculus (house mouse) ]

Gene ID: 19823, updated on 12-May-2024

Summary

Official Symbol
Rnf7provided by MGI
Official Full Name
ring finger protein 7provided by MGI
Primary source
MGI:MGI:1337096
See related
Ensembl:ENSMUSG00000051234 AllianceGenome:MGI:1337096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SAG; Rbx2
Summary
Predicted to enable NEDD8 ligase activity; cullin family protein binding activity; and ubiquitin protein ligase activity. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; brain development; and intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in brain; eye; and genitourinary system. Orthologous to human RNF7 (ring finger protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 73.0), CNS E14 (RPKM 56.6) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf7 in Genome Data Viewer
Location:
9 E3.3; 9 50.63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96352990..96360728, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96470937..96478675, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:96338415-96338742 Neighboring gene cDNA sequence BC043934 Neighboring gene predicted gene, 51656 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96378987-96379288 Neighboring gene STARR-seq mESC enhancer starr_24959 Neighboring gene predicted gene 28729 Neighboring gene STARR-seq mESC enhancer starr_24962 Neighboring gene STARR-seq mESC enhancer starr_24963 Neighboring gene ubiquitin domain containing 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NEDD8 ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RING-box protein 2
Names
sensitive to apoptosis gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311135.1NP_001298064.1  RING-box protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the central coding region that results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC161257, AK003248, AK006703, AK011328, BF018220, BY781065
    Consensus CDS
    CCDS81056.1
    UniProtKB/TrEMBL
    D3Z392
    Related
    ENSMUSP00000108581.2, ENSMUST00000071301.5
    Conserved Domains (1) summary
    cl17238
    Location:2855
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_011279.3NP_035409.1  RING-box protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161257, AK003248, AK006703, AK011328, BF018220
    Consensus CDS
    CCDS40730.1
    UniProtKB/Swiss-Prot
    Q3UKF8, Q9WTZ1
    UniProtKB/TrEMBL
    D3Z497
    Related
    ENSMUSP00000052856.5, ENSMUST00000057500.6
    Conserved Domains (1) summary
    cd16466
    Location:47106
    RING-H2_RBX2; RING finger, H2 subclass, found in RING-box protein 2 (RBX2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    96352990..96360728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)