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Rnf2 ring finger protein 2 [ Mus musculus (house mouse) ]

Gene ID: 19821, updated on 9-Jul-2024

Summary

Official Symbol
Rnf2provided by MGI
Official Full Name
ring finger protein 2provided by MGI
Primary source
MGI:MGI:1101759
See related
Ensembl:ENSMUSG00000026484 AllianceGenome:MGI:1101759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dinG; Ring1B
Summary
Enables chromatin binding activity and ubiquitin protein ligase activity. Involved in germ cell development and histone H2A-K119 monoubiquitination. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including gastrulation with mouth forming second; histone ubiquitination; and negative regulation of transcription by RNA polymerase II. Located in euchromatin; nuclear body; and sex chromatin. Part of PcG protein complex and ubiquitin ligase complex. Is expressed in several structures, including central nervous system; limb; ovary; retina; and urinary system. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 21.3), placenta adult (RPKM 21.2) and 25 other tissues See more
Orthologs
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Genomic context

See Rnf2 in Genome Data Viewer
Location:
1 G1; 1 64.15 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (151345159..151376562, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (151469398..151500991, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SWT1 RNA endoribonuclease homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E994 Neighboring gene STARR-positive B cell enhancer ABC_E5817 Neighboring gene STARR-seq mESC enhancer starr_02618 Neighboring gene tRNA methyltransferase 1 like Neighboring gene STARR-seq mESC enhancer starr_02619 Neighboring gene microRNA 7682 Neighboring gene STARR-seq mESC enhancer starr_02624 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene niban apoptosis regulator 1 Neighboring gene STARR-seq mESC enhancer starr_02626 Neighboring gene STARR-positive B cell enhancer mm9_chr1:153553362-153553663

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (9)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RING-like zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2AK119 ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of sex chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RING2
Names
RING finger protein 1B
RING-type E3 ubiquitin transferase RING2
NP_001347773.2
NP_001347774.1
NP_001347776.1
NP_001407869.1
NP_001407870.1
NP_035407.1
XP_036018760.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360844.2NP_001347773.2  E3 ubiquitin-protein ligase RING2

    Status: VALIDATED

    Source sequence(s)
    AC115060, AC165946
    UniProtKB/Swiss-Prot
    O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
  2. NM_001360845.2NP_001347774.1  E3 ubiquitin-protein ligase RING2

    Status: VALIDATED

    Source sequence(s)
    AC115060, AC165946
    Consensus CDS
    CCDS15362.1
    UniProtKB/Swiss-Prot
    O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
    Conserved Domains (3) summary
    COG5222
    Location:11103
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd16531
    Location:5191
    RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
    cd17167
    Location:225330
    RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)
  3. NM_001360847.2NP_001347776.1  E3 ubiquitin-protein ligase RING2

    Status: VALIDATED

    Source sequence(s)
    AC115060, AC165946
    Consensus CDS
    CCDS15362.1
    UniProtKB/Swiss-Prot
    O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
    Related
    ENSMUSP00000140896.2, ENSMUST00000187048.7
    Conserved Domains (3) summary
    COG5222
    Location:11103
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd16531
    Location:5191
    RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
    cd17167
    Location:225330
    RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)
  4. NM_001420940.1NP_001407869.1  E3 ubiquitin-protein ligase RING2

    Status: VALIDATED

    Source sequence(s)
    AC115060, AC165946
    UniProtKB/Swiss-Prot
    O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
  5. NM_001420941.1NP_001407870.1  E3 ubiquitin-protein ligase RING2

    Status: VALIDATED

    Source sequence(s)
    AC115060, AC165946
    UniProtKB/Swiss-Prot
    O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
  6. NM_011277.4NP_035407.1  E3 ubiquitin-protein ligase RING2

    See identical proteins and their annotated locations for NP_035407.1

    Status: VALIDATED

    Source sequence(s)
    AC115060, AC165946
    Consensus CDS
    CCDS15362.1
    UniProtKB/Swiss-Prot
    O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
    Related
    ENSMUSP00000075476.5, ENSMUST00000076110.11
    Conserved Domains (3) summary
    COG5222
    Location:11103
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd16531
    Location:5191
    RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
    cd17167
    Location:225330
    RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    151345159..151376562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162867.1XP_036018760.1  E3 ubiquitin-protein ligase RING2 isoform X2

    UniProtKB/Swiss-Prot
    O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
    Conserved Domains (3) summary
    COG5222
    Location:11103
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd16531
    Location:5191
    RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
    cd17167
    Location:225330
    RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)