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EIF4G2 eukaryotic translation initiation factor 4 gamma 2 [ Homo sapiens (human) ]

Gene ID: 1982, updated on 6-Sep-2020

Summary

Official Symbol
EIF4G2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4 gamma 2provided by HGNC
Primary source
HGNC:HGNC:3297
See related
Ensembl:ENSG00000110321 MIM:602325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P97; AAG1; DAP5; NAT1
Summary
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 207.4), placenta (RPKM 201.0) and 25 other tissues See more
Orthologs

Genomic context

See EIF4G2 in Genome Data Viewer
Location:
11p15.4
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (10797046..10808926, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10818593..10830582, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene IRAG1 antisense RNA 1 Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene uncharacterized LOC101928053 Neighboring gene uncharacterized LOC112268072 Neighboring gene small nucleolar RNA, C/D box 97 Neighboring gene uncharacterized LOC105376547

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZBED5

Homology

Clone Names

  • FLJ41344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation factor activity, RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell death TAS
Traceable Author Statement
more info
PubMed 
cellular macromolecule biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
adherens junction HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4 gamma 2
Names
DAP-5
aging-associated protein 1
death-associated protein 5
eIF-4-gamma 2
eIF-4G 2
eIF4G 2
eukaryotic translation initiation factor 4G-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042559.3NP_001036024.3  eukaryotic translation initiation factor 4 gamma 2 isoform 2

    See identical proteins and their annotated locations for NP_001036024.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AI362365, BC111548, DB072494, DB272352
    Consensus CDS
    CCDS41618.1
    UniProtKB/Swiss-Prot
    P78344
    Related
    ENSP00000379778.2, ENST00000396525.6
    Conserved Domains (4) summary
    cd11559
    Location:702838
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:506619
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:78308
    MIF4G; MIF4G domain
    pfam11235
    Location:413513
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  2. NM_001172705.1NP_001166176.1  eukaryotic translation initiation factor 4 gamma 2 isoform 1

    See identical proteins and their annotated locations for NP_001166176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AI362365, BC065276, DB231980, DB272352
    Consensus CDS
    CCDS31428.1
    UniProtKB/Swiss-Prot
    P78344
    UniProtKB/TrEMBL
    Q2TU89
    Related
    ENSP00000433664.1, ENST00000526148.5
    Conserved Domains (3) summary
    cd11559
    Location:740876
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:544657
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:78308
    MIF4G; MIF4G domain
  3. NM_001418.4NP_001409.3  eukaryotic translation initiation factor 4 gamma 2 isoform 1

    See identical proteins and their annotated locations for NP_001409.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK223548, DB272352
    Consensus CDS
    CCDS31428.1
    UniProtKB/Swiss-Prot
    P78344
    Related
    ENSP00000340281.5, ENST00000339995.10
    Conserved Domains (3) summary
    cd11559
    Location:740876
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:544657
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:78308
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    10797046..10808926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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