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EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 [ Homo sapiens (human) ]

Gene ID: 1978, updated on 28-Jun-2020

Summary

Official Symbol
EIF4EBP1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E binding protein 1provided by HGNC
Primary source
HGNC:HGNC:3288
See related
Ensembl:ENSG00000187840 MIM:602223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BP-1; 4EBP1; 4E-BP1; PHAS-I
Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in salivary gland (RPKM 30.3), fat (RPKM 26.3) and 25 other tissues See more
Orthologs

Genomic context

See EIF4EBP1 in Genome Data Viewer
Location:
8p11.23
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (38030534..38060365)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37888020..37917883)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene glutamic-oxaloacetic transaminase 1 like 1 Neighboring gene adrenoceptor beta 3 Neighboring gene Sharpr-MPRA regulatory region 54 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1253 Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit Neighboring gene RNA, U6 small nuclear 988, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag decreases EIF4EBP1 (4EBP1) associated with the 5' mRNA cap to enhance Gag translation PubMed
Vpr vpr HIV-1 Vpr expression in HEK293 cells is sufficient to decrease the levels of phosphorylated eIF4E and 4E-BP1 PubMed
nucleocapsid gag HIV-1 NC downregulates eukaryotic translation initiation factor 4E binding protein 1 in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
eukaryotic initiation factor 4E binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic initiation factor 4E binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
 
translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
IRES-dependent translational initiation of linear mRNA IEA
Inferred from Electronic Annotation
more info
 
TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to ischemia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E-binding protein 1
Names
eIF4E-binding protein 1
phosphorylated heat- and acid-stable protein regulated by insulin 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004095.4NP_004086.1  eukaryotic translation initiation factor 4E-binding protein 1

    See identical proteins and their annotated locations for NP_004086.1

    Status: REVIEWED

    Source sequence(s)
    AB044548, BC004459
    Consensus CDS
    CCDS6100.1
    UniProtKB/Swiss-Prot
    Q13541
    Related
    ENSP00000340691.4, ENST00000338825.5
    Conserved Domains (1) summary
    pfam05456
    Location:11118
    eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    38030534..38060365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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