Xpr1 xenotropic and polytropic retrovirus receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xpr1provided by MGI
Official Full Name: xenotropic and polytropic retrovirus receptor 1provided by MGI
Primary source: MGI:MGI:97932
See related: Ensembl:ENSMUSG00000026469 AllianceGenome:MGI:97932
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: XR; Sxv; Rmc1; Syg1; Rmc-1
Summary: Enables virus receptor activity. Acts upstream of or within response to virus. Predicted to be intrinsic component of plasma membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; lower jaw molar; and neural retina. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 29.3), CNS E18 (RPKM 27.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 66.49 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (155151403..155293190, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (155275657..155417444, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification.
Title: Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification.
Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors.
Title: Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors.
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate.
Title: Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate.
XPR1 Mediates the Pancreatic beta-Cell Phosphate Flush.
Title: XPR1 Mediates the Pancreatic β-Cell Phosphate Flush.
Gene expression profiles showed that XPR1 mRNA was widely expressed throughout the mouse brain.
Title: Analysis of gene expression and functional characterization of XPR1: a pathogenic gene for primary familial brain calcification.
This study evaluated the effects of XPR1 variants on XPR1 gammaretrovirus entry.
Title: Escape variants of the XPR1 gammaretrovirus receptor are rare due to reliance on a splice donor site and a short hypervariable loop.
These results show that tobacco leaves are a good heterologous system to study the transport activity of members of the PHO1/XPR1 family.
Title: Expression of the mammalian Xenotropic Polytropic Virus Receptor 1 (XPR1) in tobacco leaves leads to phosphate export.
subspecies origins of xenotropic and polytropic mouse leukemia virus endogenous retroviruses and their coevolutionary trajectory with their XPR1 receptor
Title: Endogenous gammaretrovirus acquisition in Mus musculus subspecies carrying functional variants of the XPR1 virus receptor.
results indicate that Xpr1 is a novel, atypical G-protein-coupled receptor (GPCR) and that xenotropic or polytropic retrovirus binding can disrupt the cAMP-mediated signaling function of Xpr1, leading to the apoptosis of infected cells
Title: Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity.
This study is the first to demonstrate that the expression of retro-viral receptor, XPR1, is regulated by RANKL-RANK signaling.
Title: RANKL-RANK signaling regulates expression of xenotropic and polytropic virus receptor (XPR1) in osteoclasts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234242

D1Dcr13 (e-PCR), detects polymorphism
- UniSTS:507566

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

Homology

Homologs of the Xpr1 gene: The Xpr1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 351 organisms have orthologs with human gene Xpr1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables inositol hexakisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables inositol hexakisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphate ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phosphate ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to phosphate starvation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to virus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: xenotropic and polytropic retrovirus receptor 1

Names: receptor for MCF virus 1; suppressor of yeast G<a> deletion; susceptibility to xenotropic virus; xenotropic and polytropic murine leukemia virus receptor; xenotropic and polytropic retrovirus receptor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011273.2 → NP_035403.1 xenotropic and polytropic retrovirus receptor 1

See identical proteins and their annotated locations for NP_035403.1

Status: VALIDATED

Source sequence(s)

AC110268, AF114753, AF198104, BY122762

Consensus CDS

CCDS15384.1

UniProtKB/Swiss-Prot

Q9R036, Q9Z0U0

Related

ENSMUSP00000027741.6, ENSMUST00000027741.12

Conserved Domains (3) summary

cd14477
Location:2 → 165

SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins

pfam03105
Location:3 → 169

SPX; SPX domain

pfam03124
Location:286 → 616

EXS; EXS family