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NSMCE1 NSE1 homolog, SMC5-SMC6 complex component [ Homo sapiens (human) ]

Gene ID: 197370, updated on 21-Dec-2019

Summary

Official Symbol
NSMCE1provided by HGNC
Official Full Name
NSE1 homolog, SMC5-SMC6 complex componentprovided by HGNC
Primary source
HGNC:HGNC:29897
See related
Ensembl:ENSG00000169189 MIM:617263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSE1
Expression
Ubiquitous expression in testis (RPKM 20.3), prostate (RPKM 15.1) and 25 other tissues See more
Orthologs

Genomic context

See NSMCE1 in Genome Data Viewer
Location:
16p12.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (27224994..27268772, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27236315..27280113, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371155 Neighboring gene lysine demethylase 8 Neighboring gene NSMCE1 divergent transcript Neighboring gene interleukin 4 receptor Neighboring gene interleukin 21 receptor Neighboring gene IL21R antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
non-structural maintenance of chromosomes element 1 homolog
Names
non-SMC element 1 homolog
NP_659547.2
XP_006721086.1
XP_011544064.1
XP_016878529.1
XP_016878530.1
XP_016878531.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145080.4NP_659547.2  non-structural maintenance of chromosomes element 1 homolog

    See identical proteins and their annotated locations for NP_659547.2

    Status: VALIDATED

    Source sequence(s)
    BU685363, DB463393
    Consensus CDS
    CCDS10628.2
    UniProtKB/Swiss-Prot
    Q8WV22
    Related
    ENSP00000355077.4, ENST00000361439.9
    Conserved Domains (2) summary
    pfam07574
    Location:16175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    pfam08746
    Location:191231
    zf-RING-like; RING-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    27224994..27268772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721023.4XP_006721086.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006721086.1

    UniProtKB/Swiss-Prot
    Q8WV22
    Conserved Domains (2) summary
    pfam07574
    Location:16175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    pfam08746
    Location:191231
    zf-RING-like; RING-like domain
  2. XM_011545762.1XP_011544064.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_011544064.1

    Conserved Domains (2) summary
    pfam07574
    Location:179
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    pfam08746
    Location:95135
    zf-RING-like; RING-like domain
  3. XM_017023041.1XP_016878530.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

    Conserved Domains (2) summary
    pfam07574
    Location:179
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    pfam08746
    Location:95135
    zf-RING-like; RING-like domain
  4. XM_017023040.1XP_016878529.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

    Conserved Domains (2) summary
    pfam07574
    Location:179
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    pfam08746
    Location:95135
    zf-RING-like; RING-like domain
  5. XM_017023042.1XP_016878531.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

    Conserved Domains (2) summary
    pfam07574
    Location:179
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    pfam08746
    Location:95135
    zf-RING-like; RING-like domain

RNA

  1. XR_002957792.1 RNA Sequence

    Related
    ENST00000565070.5
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