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Rgs5 regulator of G-protein signaling 5 [ Mus musculus (house mouse) ]

Gene ID: 19737, updated on 9-May-2024

Summary

Official Symbol
Rgs5provided by MGI
Official Full Name
regulator of G-protein signaling 5provided by MGI
Primary source
MGI:MGI:1098434
See related
Ensembl:ENSMUSG00000026678 AllianceGenome:MGI:1098434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110070A02Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of vascular associated smooth muscle cell proliferation and signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and visual system. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human RGS5 (regulator of G protein signaling 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 51.0), bladder adult (RPKM 48.0) and 21 other tissues See more
Orthologs
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Genomic context

See Rgs5 in Genome Data Viewer
Location:
1 H2.3; 1 76.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (169483070..169523367)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (169655501..169695813)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02975 Neighboring gene predicted gene, 34624 Neighboring gene STARR-seq mESC enhancer starr_02976 Neighboring gene predicted gene, 18900 Neighboring gene STARR-seq mESC enhancer starr_02977 Neighboring gene STARR-seq mESC enhancer starr_02978 Neighboring gene STARR-seq mESC enhancer starr_02979 Neighboring gene regulator of G-protein signaling 4 Neighboring gene predicted gene, 22114

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (7)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313705.2NP_001300634.1  regulator of G-protein signaling 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115766, AC117808
    Consensus CDS
    CCDS83629.1
    UniProtKB/TrEMBL
    A0A0A6YWD0
    Related
    ENSMUSP00000141496.2, ENSMUST00000152809.3
  2. NM_009063.5NP_033089.2  regulator of G-protein signaling 5 isoform 1

    See identical proteins and their annotated locations for NP_033089.2

    Status: VALIDATED

    Source sequence(s)
    AC115766, AC117808
    Consensus CDS
    CCDS15464.1
    UniProtKB/Swiss-Prot
    O08850, Q543B1, Q9D0Z2
    Related
    ENSMUSP00000027997.4, ENSMUST00000027997.9
    Conserved Domains (1) summary
    cd08717
    Location:65178
    RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    169483070..169523367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)