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Rgs4 regulator of G-protein signaling 4 [ Mus musculus (house mouse) ]

Gene ID: 19736, updated on 24-Jan-2023

Summary

Official Symbol
Rgs4provided by MGI
Official Full Name
regulator of G-protein signaling 4provided by MGI
Primary source
MGI:MGI:108409
See related
Ensembl:ENSMUSG00000038530 AllianceGenome:MGI:108409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM48; ESTM50
Summary
Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; regulation of ion transport; and regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including eye; genitourinary system; gut; immune system; and nervous system. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 95.1), frontal lobe adult (RPKM 57.2) and 4 other tissues See more
Orthologs
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Genomic context

See Rgs4 in Genome Data Viewer
Location:
1 H2.3; 1 76.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (169569046..169575211, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (169741477..169747642, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18900 Neighboring gene regulator of G-protein signaling 5 Neighboring gene predicted gene, 22114 Neighboring gene coiled-coil domain containing 190

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009062.3NP_033088.2  regulator of G-protein signaling 4

    See identical proteins and their annotated locations for NP_033088.2

    Status: VALIDATED

    Source sequence(s)
    AK030536, BB459021, CD741379
    Consensus CDS
    CCDS15465.1
    UniProtKB/Swiss-Prot
    O08899
    UniProtKB/TrEMBL
    Q5D078
    Related
    ENSMUSP00000027991.6, ENSMUST00000027991.12
    Conserved Domains (1) summary
    cd08714
    Location:63176
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    169569046..169575211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)