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Rgs2 regulator of G-protein signaling 2 [ Mus musculus (house mouse) ]

Gene ID: 19735, updated on 18-Sep-2018

Summary

Official Symbol
Rgs2provided by MGI
Official Full Name
regulator of G-protein signaling 2provided by MGI
Primary source
MGI:MGI:1098271
See related
Ensembl:ENSMUSG00000026360 Vega:OTTMUSG00000020882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GOS8
Expression
Biased expression in bladder adult (RPKM 52.3), CNS E14 (RPKM 14.1) and 14 other tissues See more
Orthologs

Genomic context

See Rgs2 in Genome Data Viewer
Location:
1 F; 1 62.56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (143999338..144004149, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (145846468..145851279, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ubiquitin carboxyl-terminal esterase L5 Neighboring gene predicted gene, 41964 Neighboring gene predicted gene, 35356 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene regulator of G-protein signaling 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glycine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phospholipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
relaxation of cardiac muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
relaxation of vascular smooth muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009061.4NP_033087.2  regulator of G-protein signaling 2

    See identical proteins and their annotated locations for NP_033087.2

    Status: VALIDATED

    Source sequence(s)
    AK029310, AK031603
    Consensus CDS
    CCDS15347.1
    UniProtKB/Swiss-Prot
    O08849
    Related
    ENSMUSP00000115558.1, OTTMUSP00000022856, ENSMUST00000127206.7, OTTMUST00000049364
    Conserved Domains (1) summary
    cd08709
    Location:84197
    RGS_RGS2; Regulator of G protein signaling (RGS) domain found in the RGS2 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    143999338..144004149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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