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EME2 essential meiotic structure-specific endonuclease subunit 2 [ Homo sapiens (human) ]

Gene ID: 197342, updated on 11-Jun-2021

Summary

Official Symbol
EME2provided by HGNC
Official Full Name
essential meiotic structure-specific endonuclease subunit 2provided by HGNC
Primary source
HGNC:HGNC:27289
See related
Ensembl:ENSG00000197774 MIM:610886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLX2B; gs125
Summary
EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 3.4), duodenum (RPKM 3.1) and 24 other tissues See more
Orthologs
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Genomic context

See EME2 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1772810..1781702)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1822811..1831703)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene microRNA 3177 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene nucleotide binding protein 2 Neighboring gene insulin like growth factor binding protein acid labile subunit

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00151

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable crossover junction endonuclease EME2
Names
SLX2 structure-specific endonuclease subunit homolog B
essential meiotic endonuclease 1 homolog 2
homolog of yeast EME1 endonuclease 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257370.2NP_001244299.1  probable crossover junction endonuclease EME2

    See identical proteins and their annotated locations for NP_001244299.1

    Status: VALIDATED

    Source sequence(s)
    AC012180
    Consensus CDS
    CCDS58404.1
    UniProtKB/Swiss-Prot
    A4GXA9
    Related
    ENSP00000457353.1, ENST00000568449.7
    Conserved Domains (1) summary
    pfam02732
    Location:177249
    ERCC4; ERCC4 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1772810..1781702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023026.1XP_016878515.1  probable crossover junction endonuclease EME2 isoform X2

  2. XM_017023025.1XP_016878514.1  probable crossover junction endonuclease EME2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001010865.1: Suppressed sequence

    Description
    NM_001010865.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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