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ZNF778 zinc finger protein 778 [ Homo sapiens (human) ]

Gene ID: 197320, updated on 12-Oct-2019

Summary

Official Symbol
ZNF778provided by HGNC
Official Full Name
zinc finger protein 778provided by HGNC
Primary source
HGNC:HGNC:26479
See related
Ensembl:ENSG00000170100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in testis (RPKM 3.1), brain (RPKM 2.1) and 25 other tissues See more
Orthologs

Genomic context

See ZNF778 in Genome Data Viewer
Location:
16q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (89202112..89237071)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89284111..89302402)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cadherin 15 Neighboring gene solute carrier family 22 member 31 Neighboring gene uncharacterized LOC105371413 Neighboring gene ankyrin repeat domain 11 Neighboring gene uncharacterized LOC105371414

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31875, MGC150573

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028146.1 RefSeqGene

    Range
    5001..16855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_284

mRNA and Protein(s)

  1. NM_001201407.1NP_001188336.1  zinc finger protein 778 isoform 1

    See identical proteins and their annotated locations for NP_001188336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC009113, BC143524, DA297948, DR001516
    Consensus CDS
    CCDS73928.1
    UniProtKB/TrEMBL
    A0A0A0MSW5
    Related
    ENSP00000405289.3, ENST00000433976.6
    Conserved Domains (5) summary
    smart00349
    Location:42100
    KRAB; krueppel associated box
    COG5048
    Location:380747
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591611
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4281
    KRAB; KRAB box
    pfam13465
    Location:603628
    zf-H2C2_2; Zinc-finger double domain
  2. NM_182531.4NP_872337.2  zinc finger protein 778 isoform 2

    See identical proteins and their annotated locations for NP_872337.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC009113, AK056437, DA297948
    Consensus CDS
    CCDS45550.1
    UniProtKB/Swiss-Prot
    Q96MU6
    Related
    ENSP00000481538.1, ENST00000620195.4
    Conserved Domains (5) summary
    smart00349
    Location:4282
    KRAB; krueppel associated box
    COG5048
    Location:352719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:563583
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4281
    KRAB; KRAB box
    pfam13465
    Location:575600
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_037705.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the CDS, resulting in frame-shift and an immature translation termination, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate.
    Source sequence(s)
    AC009113, BC143524, DA297948, DC324714

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    89202112..89237071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522940.2XP_011521242.1  zinc finger protein 778 isoform X1

    See identical proteins and their annotated locations for XP_011521242.1

    UniProtKB/TrEMBL
    A0A0A0MSW5
    Conserved Domains (5) summary
    smart00349
    Location:42100
    KRAB; krueppel associated box
    COG5048
    Location:380747
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591611
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4281
    KRAB; KRAB box
    pfam13465
    Location:603628
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017023015.1XP_016878504.1  zinc finger protein 778 isoform X3

    UniProtKB/Swiss-Prot
    Q96MU6
    Related
    ENSP00000305203.6, ENST00000306502.6
  3. XM_005256288.2XP_005256345.1  zinc finger protein 778 isoform X1

    See identical proteins and their annotated locations for XP_005256345.1

    UniProtKB/TrEMBL
    A0A0A0MSW5
    Conserved Domains (5) summary
    smart00349
    Location:42100
    KRAB; krueppel associated box
    COG5048
    Location:380747
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591611
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4281
    KRAB; KRAB box
    pfam13465
    Location:603628
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017023016.1XP_016878505.1  zinc finger protein 778 isoform X5

  5. XM_017023017.1XP_016878506.1  zinc finger protein 778 isoform X6

  6. XM_024450182.1XP_024305950.1  zinc finger protein 778 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:317684
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:528548
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_024450184.1XP_024305952.1  zinc finger protein 778 isoform X5

  8. XM_024450185.1XP_024305953.1  zinc finger protein 778 isoform X5

  9. XM_024450183.1XP_024305951.1  zinc finger protein 778 isoform X4

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