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ZNF778 zinc finger protein 778 [ Homo sapiens (human) ]

Gene ID: 197320, updated on 6-Sep-2021

Summary

Official Symbol
ZNF778provided by HGNC
Official Full Name
zinc finger protein 778provided by HGNC
Primary source
HGNC:HGNC:26479
See related
Ensembl:ENSG00000170100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in testis (RPKM 3.1), brain (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF778 in Genome Data Viewer
Location:
16q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (89202112..89237141)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89284111..89303549)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cadherin 15 Neighboring gene solute carrier family 22 member 31 Neighboring gene uncharacterized LOC105371413 Neighboring gene ankyrin repeat domain 11 Neighboring gene uncharacterized LOC105371414

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31875, MGC150573

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028146.1 RefSeqGene

    Range
    5001..16855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_284

mRNA and Protein(s)

  1. NM_001201407.2NP_001188336.1  zinc finger protein 778 isoform 1

    See identical proteins and their annotated locations for NP_001188336.1

    Status: REVIEWED

    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS73928.1
    UniProtKB/TrEMBL
    A0A0A0MSW5
    Related
    ENSP00000405289.3, ENST00000433976.7
    Conserved Domains (3) summary
    smart00349
    Location:42100
    KRAB; krueppel associated box
    COG5048
    Location:380747
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591611
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001378881.1NP_001365810.1  zinc finger protein 778 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009113
    Conserved Domains (3) summary
    smart00349
    Location:42100
    KRAB; krueppel associated box
    COG5048
    Location:380747
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591611
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_182531.5NP_872337.2  zinc finger protein 778 isoform 2

    See identical proteins and their annotated locations for NP_872337.2

    Status: REVIEWED

    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS45550.1
    UniProtKB/Swiss-Prot
    Q96MU6
    Related
    ENSP00000481538.1, ENST00000620195.4
    Conserved Domains (5) summary
    smart00349
    Location:4282
    KRAB; krueppel associated box
    COG5048
    Location:352719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:563583
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4281
    KRAB; KRAB box
    pfam13465
    Location:575600
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_037705.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009113

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    89202112..89237141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522940.2XP_011521242.1  zinc finger protein 778 isoform X1

    See identical proteins and their annotated locations for XP_011521242.1

    UniProtKB/TrEMBL
    A0A0A0MSW5
    Conserved Domains (3) summary
    smart00349
    Location:42100
    KRAB; krueppel associated box
    COG5048
    Location:380747
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591611
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017023015.1XP_016878504.1  zinc finger protein 778 isoform X3

    UniProtKB/Swiss-Prot
    Q96MU6
    Related
    ENSP00000305203.6, ENST00000306502.6
  3. XM_017023016.1XP_016878505.1  zinc finger protein 778 isoform X5

  4. XM_017023017.1XP_016878506.1  zinc finger protein 778 isoform X6

  5. XM_024450182.1XP_024305950.1  zinc finger protein 778 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:317684
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:528548
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_024450184.1XP_024305952.1  zinc finger protein 778 isoform X5

  7. XM_024450185.1XP_024305953.1  zinc finger protein 778 isoform X5

  8. XM_024450183.1XP_024305951.1  zinc finger protein 778 isoform X4

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