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Rgl2 ral guanine nucleotide dissociation stimulator-like 2 [ Mus musculus (house mouse) ]

Gene ID: 19732, updated on 4-Jul-2019

Summary

Official Symbol
Rgl2provided by MGI
Official Full Name
ral guanine nucleotide dissociation stimulator-like 2provided by MGI
Primary source
MGI:MGI:107483
See related
Ensembl:ENSMUSG00000041354
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rlf; Rgt2; KE1.5; Rab2l
Expression
Ubiquitous expression in thymus adult (RPKM 47.5), spleen adult (RPKM 34.2) and 28 other tissues See more
Orthologs

Genomic context

See Rgl2 in Genome Data Viewer
Location:
17; 17 B1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (33929527..33937687)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34066839..34074632)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein Neighboring gene prefoldin subunit 6 Neighboring gene WD repeat domain 46

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ral guanine nucleotide dissociation stimulator-like 2
Names
RalGDS-like factor
ralGDS-like 2
ras-associated protein RAB2L

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009059.2NP_033085.2  ral guanine nucleotide dissociation stimulator-like 2

    See identical proteins and their annotated locations for NP_033085.2

    Status: PROVISIONAL

    Source sequence(s)
    BC068121
    Consensus CDS
    CCDS28635.1
    UniProtKB/Swiss-Prot
    Q61193
    Related
    ENSMUSP00000041082.9, ENSMUST00000047503.15
    Conserved Domains (3) summary
    cd00153
    Location:649734
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:239513
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:90212
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    33929527..33937687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523911.2XP_006523974.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    See identical proteins and their annotated locations for XP_006523974.1

    Conserved Domains (2) summary
    smart00229
    Location:90212
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:239414
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  2. XM_006523910.1XP_006523973.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006523973.1

    Conserved Domains (3) summary
    cd00153
    Location:536621
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:126400
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:199
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RNA

  1. XR_385304.2 RNA Sequence

Reference GRCm38.p4 129X1/SvJ

Genomic

  1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

    Range
    178657..186450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    238731..246470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

    Range
    238843..246582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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