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Rgl2 ral guanine nucleotide dissociation stimulator-like 2 [ Mus musculus (house mouse) ]

Gene ID: 19732, updated on 8-Dec-2022

Summary

Official Symbol
Rgl2provided by MGI
Official Full Name
ral guanine nucleotide dissociation stimulator-like 2provided by MGI
Primary source
MGI:MGI:107483
See related
Ensembl:ENSMUSG00000041354 AllianceGenome:MGI:107483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rlf; Rgt2; KE1.5; Rab2l
Summary
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; integumental system; and nervous system. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 47.5), spleen adult (RPKM 34.2) and 28 other tissues See more
Orthologs
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Genomic context

See Rgl2 in Genome Data Viewer
Location:
17; 17 B1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34148813..34156661)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33929514..33937687)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein Neighboring gene prefoldin subunit 6 Neighboring gene WD repeat domain 46

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

General protein information

Preferred Names
ral guanine nucleotide dissociation stimulator-like 2
Names
RalGDS-like factor
ralGDS-like 2
ras-associated protein RAB2L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410640.1NP_001397569.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR974462
  2. NM_001410641.1NP_001397570.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974462
  3. NM_001410645.1NP_001397574.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974462
  4. NM_001410646.1NP_001397575.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974462
  5. NM_001410647.1NP_001397576.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974462
  6. NM_009059.3NP_033085.2  ral guanine nucleotide dissociation stimulator-like 2 isoform 1

    See identical proteins and their annotated locations for NP_033085.2

    Status: VALIDATED

    Source sequence(s)
    CR974462
    Consensus CDS
    CCDS28635.1
    UniProtKB/Swiss-Prot
    Q61193, Q9QUJ2
    Related
    ENSMUSP00000041082.10, ENSMUST00000047503.16
    Conserved Domains (3) summary
    cd00153
    Location:649734
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:239513
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:90212
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RNA

  1. NR_177102.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974462
  2. NR_177103.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974462
  3. NR_177105.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974462

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34148813..34156661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523910.2XP_006523973.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006523973.1

    Conserved Domains (3) summary
    smart00147
    Location:126400
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:199
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd17211
    Location:536621
    RA_RGL2; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) and similar proteins

RNA

  1. XR_385304.4 RNA Sequence

  2. XR_003952098.2 RNA Sequence