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Rgl1 ral guanine nucleotide dissociation stimulator,-like 1 [ Mus musculus (house mouse) ]

Gene ID: 19731, updated on 26-Sep-2022

Summary

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Official Symbol
Rgl1provided by MGI
Official Full Name
ral guanine nucleotide dissociation stimulator,-like 1provided by MGI
Primary source
MGI:MGI:107484
See related
Ensembl:ENSMUSG00000026482 AllianceGenome:MGI:107484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rgl; mKIAA0959
Summary
This gene encodes a member of the Ras-like (Ral) -selective guanine nucleotide exchange factor (RalGEF) family of small GTPase activators which function both as downstream effectors of activated Ras GTPase and as regulators of certain Ral GTPases in the RalGEF - Ral GTPase signaling pathway. The encoded protein, like other RalGEFs, has an N-terminal ras exchanger motif domain, a catalytic CDC25 homology domain, and a C-terminal ras binding domain that stimulates guanine nucleotide exchange when bound to a Ral GTPase. RalGEF family members bridge the Ras and Ral signaling pathways and are thought to play a role in oncogenic transformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in kidney adult (RPKM 21.8), placenta adult (RPKM 12.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Rgl1 in Genome Data Viewer
Location:
1; 1 G2- G3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (152392513..152642089, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (152516762..152766308, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene collagen beta(1-O)galactosyltransferase 2 Neighboring gene basic transcription factor 3, pseudogene 14 Neighboring gene predicted gene, 51749 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) Neighboring gene actin related protein 2/3 complex, subunit 5 Neighboring gene neutrophil cytosolic factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Gentry LR, et al. Biochim Biophys Acta, 2014 Dec. PMID 25219551, Free PMC Article
  2. The RalGEF/Ral pathway: evaluating an intervention opportunity for Ras cancers. Cooper JM, et al. Enzymes, 2013. PMID 25034103
  3. RalGDS family members couple Ras to Ral signalling and that's not all. Ferro E, et al. Cell Signal, 2010 Dec. PMID 20478380
  4. ralGDS family members interact with the effector loop of ras p21. Kikuchi A, et al. Mol Cell Biol, 1994 Nov. PMID 7935463, Free PMC Article
  5. RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. Wolthuis RM, et al. Oncogene, 1996 Jul 18. PMID 8710374

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rgl1 expression was strongly reduced by COX-2 deletion across all examined tissues.
    Title: COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0959

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
ral guanine nucleotide dissociation stimulator-like 1
Names
ralGDS-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346117.1 → NP_001333046.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
    Consensus CDS
    CCDS87891.1
    UniProtKB/Swiss-Prot
    Q60695
    UniProtKB/TrEMBL
    E9Q8M9
    Conserved Domains (3) summary
    smart00229
    Location:100 → 231
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:263 → 532
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:682 → 768
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

  2. NM_001346118.1 → NP_001333047.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
    Consensus CDS
    CCDS87891.1
    UniProtKB/Swiss-Prot
    Q60695
    UniProtKB/TrEMBL
    E9Q8M9
    Related
    ENSMUSP00000107490.2, ENSMUST00000111859.8
    Conserved Domains (3) summary
    smart00229
    Location:100 → 231
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:263 → 532
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:682 → 768
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

  3. NM_001346119.1 → NP_001333048.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
    Consensus CDS
    CCDS87890.1
    UniProtKB/Swiss-Prot
    Q60695
    UniProtKB/TrEMBL
    E9Q8N0
    Related
    ENSMUSP00000107488.2, ENSMUST00000111857.3
    Conserved Domains (3) summary
    smart00229
    Location:63 → 194
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:226 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:645 → 731
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

  4. NM_016846.4 → NP_058542.2  ral guanine nucleotide dissociation stimulator-like 1 isoform 3

    See identical proteins and their annotated locations for NP_058542.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (3) with a shorter and distinct N-terminus, compared to isoform 1
    Source sequence(s)
    AC118051, AC123732, AK169109
    Consensus CDS
    CCDS15365.1
    UniProtKB/Swiss-Prot
    Q60695, Q8VD09
    Related
    ENSMUSP00000027760.8, ENSMUST00000027760.14
    Conserved Domains (3) summary
    cd00153
    Location:648 → 733
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00229
    Location:65 → 196
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:228 → 497
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    152392513..152642089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162813.1 → XP_036018706.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

    UniProtKB/TrEMBL
    E9Q8N0
    Conserved Domains (3) summary
    smart00229
    Location:63 → 194
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:226 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:645 → 731
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

  2. XM_006529268.5 → XP_006529331.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

    Conserved Domains (3) summary
    smart00229
    Location:20 → 151
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:183 → 452
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:602 → 688
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

  3. XM_006529267.5 → XP_006529330.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

    Conserved Domains (2) summary
    cd00155
    Location:51 → 320
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:470 → 556
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

  4. XM_006529266.5 → XP_006529329.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

    UniProtKB/TrEMBL
    E9Q8N0
    Conserved Domains (3) summary
    smart00229
    Location:63 → 194
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:226 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:645 → 731
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60695.2 GenPept UniProtKB/Swiss-Prot:Q60695

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