Format

Send to:

Choose Destination

Ralgds ral guanine nucleotide dissociation stimulator [ Mus musculus (house mouse) ]

Gene ID: 19730, updated on 8-Jul-2018
Official Symbol
Ralgdsprovided by MGI
Official Full Name
ral guanine nucleotide dissociation stimulatorprovided by MGI
Primary source
MGI:MGI:107485
See related
Ensembl:ENSMUSG00000026821 Vega:OTTMUSG00000011643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gnds; Rgds; mKIAA1308
Expression
Ubiquitous expression in testis adult (RPKM 54.6), colon adult (RPKM 48.6) and 24 other tissues See more
Orthologs
See Ralgds in Genome Data Viewer
Location:
2; 2 A3
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (28513089..28553082)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (28368687..28408602)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Neighboring gene carboxyl ester lipase Neighboring gene general transcription factor IIIC, polypeptide 5

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
    Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Choline metabolism in cancer, conserved biosystem (from KEGG)
    Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pancreatic cancer, organism-specific biosystem (from KEGG)
    Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pancreatic cancer, conserved biosystem (from KEGG)
    Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signalling to ERKs, organism-specific biosystem (from REACTOME)
    Signalling to ERKs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signalling to RAS, organism-specific biosystem (from REACTOME)
    Signalling to RAS, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • p38MAPK events, organism-specific biosystem (from REACTOME)
    p38MAPK events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
signal transduction IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
brush border ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ral guanine nucleotide dissociation stimulator
Names
ral guanine nucleotide exchange factor
ralGEF

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145834.1NP_001139306.1  ral guanine nucleotide dissociation stimulator isoform 4

    See identical proteins and their annotated locations for NP_001139306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site at the 5' end of an exon and differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) lacks an internal segment and has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK141959, CF537148, CF585220
    UniProtKB/TrEMBL
    Q3UQY9
    Conserved Domains (3) summary
    cd00153
    Location:724809
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:308575
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:57181
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  2. NM_001145835.1NP_001139307.1  ral guanine nucleotide dissociation stimulator isoform 1

    See identical proteins and their annotated locations for NP_001139307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK159020, AK159754, BY346626, CF585220
    Consensus CDS
    CCDS50547.1
    UniProtKB/TrEMBL
    Q3TWC1, Q3TXZ3
    Related
    ENSMUSP00000097812.3, OTTMUSP00000012394, ENSMUST00000100241.9, OTTMUST00000027250
    Conserved Domains (3) summary
    cd00153
    Location:791876
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:375642
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:112248
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  3. NM_001145836.1NP_001139308.1  ral guanine nucleotide dissociation stimulator isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK129328, AK159020, BY346626, CF585220
    Consensus CDS
    CCDS50548.1
    UniProtKB/TrEMBL
    A2AK33, Q3TXZ3, Q6ZPU1
    Related
    ENSMUSP00000109526.1, OTTMUSP00000012395, ENSMUST00000113893.7, OTTMUST00000027251
    Conserved Domains (3) summary
    cd00153
    Location:779864
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:363630
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:112236
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  4. NM_009058.2NP_033084.2  ral guanine nucleotide dissociation stimulator isoform 3

    See identical proteins and their annotated locations for NP_033084.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK129328, CF537148, CF585220
    Consensus CDS
    CCDS15840.1
    UniProtKB/Swiss-Prot
    Q03385
    UniProtKB/TrEMBL
    Q6ZPU1
    Related
    ENSMUSP00000028170.8, OTTMUSP00000012393, ENSMUST00000028170.14, OTTMUST00000027249
    Conserved Domains (3) summary
    cd00153
    Location:736821
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:320587
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:57193
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    28513089..28553082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497798.3XP_006497861.1  ral guanine nucleotide dissociation stimulator isoform X3

    Conserved Domains (3) summary
    cd00153
    Location:737822
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:321588
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:57194
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  2. XM_006497797.3XP_006497860.1  ral guanine nucleotide dissociation stimulator isoform X2

    Conserved Domains (3) summary
    cd00153
    Location:734819
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:376643
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:112249
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  3. XM_006497796.3XP_006497859.1  ral guanine nucleotide dissociation stimulator isoform X1

    Conserved Domains (3) summary
    cd00153
    Location:792877
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:376643
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:112249
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  4. XM_006497799.3XP_006497862.1  ral guanine nucleotide dissociation stimulator isoform X4

    Conserved Domains (2) summary
    cd00153
    Location:560645
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:144411
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
Support Center