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Rfx2 regulatory factor X, 2 (influences HLA class II expression) [ Mus musculus (house mouse) ]

Gene ID: 19725, updated on 27-Nov-2024

Summary

Official Symbol
Rfx2provided by MGI
Official Full Name
regulatory factor X, 2 (influences HLA class II expression)provided by MGI
Primary source
MGI:MGI:106583
See related
Ensembl:ENSMUSG00000024206 AllianceGenome:MGI:106583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430432H19Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in acrosome assembly; cilium assembly; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; liver; ovary; primitive streak; and sensory organ. Orthologous to human RFX2 (regulatory factor X2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 137.0), ovary adult (RPKM 9.7) and 4 other tissues See more
Orthologs
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Genomic context

See Rfx2 in Genome Data Viewer
Location:
17 D; 17 29.5 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57082897..57138102, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56775897..56831008, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5624 Neighboring gene dihydrouridine synthase 3 like Neighboring gene proline rich 22 Neighboring gene predicted gene, 41604 Neighboring gene STARR-positive B cell enhancer ABC_E5625 Neighboring gene STARR-seq mESC enhancer starr_42905 Neighboring gene acyl-CoA synthetase bubblegum family member 2 Neighboring gene STARR-seq mESC enhancer starr_42911 Neighboring gene acyl-CoA synthetase bubblegum family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
DNA-binding protein RFX2
Names
regulatory factor X 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009056.3NP_033082.1  DNA-binding protein RFX2 isoform 2

    See identical proteins and their annotated locations for NP_033082.1

    Status: VALIDATED

    Source sequence(s)
    CT010491
    Consensus CDS
    CCDS28915.1
    UniProtKB/Swiss-Prot
    P48379
    Related
    ENSMUSP00000084010.6, ENSMUST00000086801.7
    Conserved Domains (2) summary
    pfam02257
    Location:166242
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:19148
    RFX1_trans_act; RFX1 transcription activation region
  2. NM_027787.2NP_082063.1  DNA-binding protein RFX2 isoform 1

    See identical proteins and their annotated locations for NP_082063.1

    Status: VALIDATED

    Source sequence(s)
    CT010491
    Consensus CDS
    CCDS50156.1
    UniProtKB/Swiss-Prot
    P48379, Q8BXR3
    Related
    ENSMUSP00000002444.8, ENSMUST00000002444.15
    Conserved Domains (2) summary
    pfam02257
    Location:195267
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:19148
    RFX1_trans_act; RFX1 transcription activation region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57082897..57138102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160421.1XP_036016314.1  DNA-binding protein RFX2 isoform X1

    Conserved Domains (2) summary
    pfam02257
    Location:152224
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:1105
    RFX1_trans_act; RFX1 transcription activation region