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Rfx2 regulatory factor X, 2 (influences HLA class II expression) [ Mus musculus (house mouse) ]

Gene ID: 19725, updated on 5-Aug-2018

Summary

Official Symbol
Rfx2provided by MGI
Official Full Name
regulatory factor X, 2 (influences HLA class II expression)provided by MGI
Primary source
MGI:MGI:106583
See related
Ensembl:ENSMUSG00000024206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430432H19Rik
Expression
Biased expression in testis adult (RPKM 137.0), ovary adult (RPKM 9.7) and 4 other tissues See more
Orthologs

Genomic context

See Rfx2 in Genome Data Viewer
Location:
17 D; 17 29.5 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (56775897..56831008, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (56915320..56970431, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene dihydrouridine synthase 3-like (S. cerevisiae) Neighboring gene proline rich 22 Neighboring gene predicted gene, 41604 Neighboring gene acyl-CoA synthetase bubblegum family member 2 Neighboring gene RIKEN cDNA 1700061G19 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acrosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-binding protein RFX2
Names
regulatory factor X 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009056.2NP_033082.1  DNA-binding protein RFX2 isoform 2

    See identical proteins and their annotated locations for NP_033082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK044439, CT010491
    Consensus CDS
    CCDS28915.1
    UniProtKB/Swiss-Prot
    P48379
    Related
    ENSMUSP00000084010.5, ENSMUST00000086801.5
    Conserved Domains (2) summary
    pfam02257
    Location:166242
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:19148
    RFX1_trans_act; RFX1 transcription activation region
  2. NM_027787.1NP_082063.1  DNA-binding protein RFX2 isoform 1

    See identical proteins and their annotated locations for NP_082063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK044439, CT010491
    Consensus CDS
    CCDS50156.1
    UniProtKB/Swiss-Prot
    P48379
    Related
    ENSMUSP00000002444.7, ENSMUST00000002444.13
    Conserved Domains (2) summary
    pfam02257
    Location:195267
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:19148
    RFX1_trans_act; RFX1 transcription activation region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    56775897..56831008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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