U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rfc2 replication factor C (activator 1) 2 [ Mus musculus (house mouse) ]

Gene ID: 19718, updated on 14-May-2024

Summary

Official Symbol
Rfc2provided by MGI
Official Full Name
replication factor C (activator 1) 2provided by MGI
Primary source
MGI:MGI:1341868
See related
Ensembl:ENSMUSG00000023104 AllianceGenome:MGI:1341868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
40kDa; Recc2; 2610008M13Rik
Summary
Enables enzyme binding activity. Predicted to be involved in DNA repair; DNA-dependent DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within DNA replication. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC2 (replication factor C subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 104.6), liver E14 (RPKM 51.0) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rfc2 in Genome Data Viewer
Location:
5 G2; 5 74.68 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134611544..134627182)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134582690..134598328)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11305 Neighboring gene STARR-positive B cell enhancer ABC_E9653 Neighboring gene syncytin a Neighboring gene microRNA 7228 Neighboring gene STARR-positive B cell enhancer ABC_E3628 Neighboring gene STARR-positive B cell enhancer ABC_E8085 Neighboring gene linker for activation of T cells family, member 2 Neighboring gene eukaryotic translation initiation factor 4H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117486

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
 
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of DNA replication factor C complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
replication factor C subunit 2
Names
A1 40 kDa subunit
RF-C 40 kDa subunit
RFC40
activator 1 40 kDa subunit
activator 1 subunit 2
replication factor C 40 kDa subunit
replication factor C, 40 kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020022.2NP_064406.1  replication factor C subunit 2

    See identical proteins and their annotated locations for NP_064406.1

    Status: VALIDATED

    Source sequence(s)
    AK075997, BY338186
    Consensus CDS
    CCDS19722.1
    UniProtKB/Swiss-Prot
    Q9WUK4
    UniProtKB/TrEMBL
    Q4KL82, Q9D0K3
    Related
    ENSMUSP00000023867.7, ENSMUST00000023867.8
    Conserved Domains (4) summary
    cd00009
    Location:46180
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    PLN03025
    Location:31343
    PLN03025; replication factor C subunit; Provisional
    pfam08542
    Location:269337
    Rep_fac_C; Replication factor C C-terminal domain
    pfam16193
    Location:203231
    AAA_assoc_2; AAA C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134611544..134627182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)