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LCTL lactase like [ Homo sapiens (human) ]

Gene ID: 197021, updated on 25-Nov-2021

Summary

Official Symbol
LCTLprovided by HGNC
Official Full Name
lactase likeprovided by HGNC
Primary source
HGNC:HGNC:15583
See related
Ensembl:ENSG00000188501 MIM:617060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLG; KLPH
Summary
This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Broad expression in testis (RPKM 4.1), lymph node (RPKM 0.7) and 20 other tissues See more
Orthologs
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Genomic context

See LCTL in Genome Data Viewer
Location:
15q22.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (66547532..66565998, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66839517..66858336, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 18A Neighboring gene small nucleolar RNA, C/D box 16 Neighboring gene zwilch kinetochore protein Neighboring gene ribosomal protein L4 Neighboring gene long intergenic non-protein coding RNA 1169 Neighboring gene Sharpr-MPRA regulatory region 4382 Neighboring gene SMAD family member 6 Neighboring gene HNF4 motif-containing MPRA enhancer 143

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lens morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in brush border IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lactase-like protein
Names
KL lactase phlorizin hydrolase
gammaklotho
klotho gamma
klotho/lactase-phlorizin hydrolase-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278562.3NP_001265491.1  lactase-like protein isoform 2

    See identical proteins and their annotated locations for NP_001265491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC116913
    Consensus CDS
    CCDS61678.1
    UniProtKB/Swiss-Prot
    Q6UWM7
    Related
    ENSP00000445419.1, ENST00000537670.5
    Conserved Domains (1) summary
    cl23725
    Location:4330
    Glyco_hydro_1; Glycosyl hydrolase family 1
  2. NM_001394632.1NP_001381561.1  lactase-like protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC116913
    Conserved Domains (1) summary
    cl23725
    Location:2264
    Glyco_hydro; Glycosyl hydrolases
  3. NM_001394633.1NP_001381562.1  lactase-like protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC116913
    Conserved Domains (1) summary
    cl23725
    Location:5235
    Glyco_hydro; Glycosyl hydrolases
  4. NM_207338.4NP_997221.2  lactase-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_997221.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC116913
    Consensus CDS
    CCDS10220.1
    UniProtKB/Swiss-Prot
    Q6UWM7
    Related
    ENSP00000343490.5, ENST00000341509.9
    Conserved Domains (1) summary
    cl23725
    Location:33503
    Glyco_hydro_1; Glycosyl hydrolase family 1

RNA

  1. NR_103739.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon and lacks several internal exons compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC116913
  2. NR_172140.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC116913

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    66547532..66565998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449870.1XP_024305638.1  lactase-like protein isoform X2

    Conserved Domains (1) summary
    cl23725
    Location:4268
    Glyco_hydro_1; Glycosyl hydrolase family 1
  2. XM_024449869.1XP_024305637.1  lactase-like protein isoform X1

    Conserved Domains (1) summary
    cl23725
    Location:4330
    Glyco_hydro_1; Glycosyl hydrolase family 1
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