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Ren2 renin 2 tandem duplication of Ren1 [ Mus musculus (house mouse) ]

Gene ID: 19702, updated on 25-May-2017
Official Symbol
Ren2provided by MGI
Official Full Name
renin 2 tandem duplication of Ren1provided by MGI
Primary source
MGI:MGI:97899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ren; Rnr; Rn-2; Ren-2; Ren-B
Annotation information
Annotation category: only annotated on alternate loci in reference assembly
See Ren2 in Map Viewer
Location:
1 E4; 1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 Unlocalized Scaffold (129S6/SvEvTac) NT_039192.2 (159748..169505, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 (129/SvEvTac) NT_039192.2 (159748..169505, complement)

NT_039192.2Genomic Context describing neighboring genes Neighboring gene renin 1 structural Neighboring gene ethanolamine kinase 2-like Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene golgi transport 1A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
    ACE Inhibitor Pathway, organism-specific biosystemThe renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representatio...
  • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
    Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiotensin maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
renin-2
Names
angiotensinogenase
submandibular gland renin
NP_112470.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031193.2NP_112470.2  renin-2

    Status: VALIDATED

    Source sequence(s)
    BC011157, BG867251, BG869802
    UniProtKB/Swiss-Prot
    P00796
    Conserved Domains (3) summary
    cd05487
    Location:98423
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam00026
    Location:105423
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:5176
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 129S6/SvEvTac

Genomic

  1. NT_039192.2 Reference GRCm38.p4 129S6/SvEvTac

    Range
    159748..169505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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