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Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) [ Mus musculus (house mouse) ]

Gene ID: 19697, updated on 25-Sep-2020

Summary

Official Symbol
Relaprovided by MGI
Official Full Name
v-rel reticuloendotheliosis viral oncogene homolog A (avian)provided by MGI
Primary source
MGI:MGI:103290
See related
Ensembl:ENSMUSG00000024927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p6; p65; p65 NFkB; p65 NF-kappa B
Expression
Ubiquitous expression in adrenal adult (RPKM 78.1), lung adult (RPKM 46.5) and 28 other tissues See more
Orthologs

Genomic context

See Rela in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5687569..5698162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5637442..5648134)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5637490..5648130)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ribonuclease H2, subunit C Neighboring gene K(lysine) acetyltransferase 5 Neighboring gene signal-induced proliferation associated gene 1 Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
RNA polymerase II transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
actinin binding IPI
Inferred from Physical Interaction
more info
PubMed 
actinin binding ISO
Inferred from Sequence Orthology
more info
 
activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
ankyrin repeat binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
phosphate ion binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NIK/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to angiotensin ISO
Inferred from Sequence Orthology
more info
 
cellular response to biotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipoteichoic acid ISO
Inferred from Sequence Orthology
more info
 
cellular response to nicotine ISO
Inferred from Sequence Orthology
more info
 
cellular response to peptidoglycan ISO
Inferred from Sequence Orthology
more info
 
cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Schwann cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
positive regulation of miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
postsynapse to nucleus signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse to nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA-templated transcription in response to stress ISO
Inferred from Sequence Orthology
more info
 
regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to UV-B ISO
Inferred from Sequence Orthology
more info
 
response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle stretch IDA
Inferred from Direct Assay
more info
PubMed 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
NF-kappaB complex TAS
Traceable Author Statement
more info
PubMed 
NF-kappaB p50/p65 complex ISO
Inferred from Sequence Orthology
more info
 
NF-kappaB p50/p65 complex NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor p65
Names
avian reticuloendotheliosis viral (v-rel) oncogene homolog A
nuclear factor NF-kappa-B p65 subunit
nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365067.1NP_001351996.1  transcription factor p65 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126029, AC134563
    Conserved Domains (3) summary
    cd01177
    Location:144240
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cl08275
    Location:93137
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    cl26464
    Location:205471
    Atrophin-1; Atrophin-1 family
  2. NM_009045.5NP_033071.1  transcription factor p65 isoform 1

    See identical proteins and their annotated locations for NP_033071.1

    Status: VALIDATED

    Source sequence(s)
    AC126029, AC134563
    Consensus CDS
    CCDS29473.1
    UniProtKB/Swiss-Prot
    Q04207
    UniProtKB/TrEMBL
    Q548Y4
    Related
    ENSMUSP00000025867.5, ENSMUST00000025867.5
    Conserved Domains (2) summary
    cd07885
    Location:19187
    RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA
    cd01177
    Location:194290
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5687569..5698162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531694.4XP_006531757.1  transcription factor p65 isoform X1

    Conserved Domains (2) summary
    cd07885
    Location:26194
    RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA
    cd01177
    Location:201297
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
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