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ADCY4 adenylate cyclase 4 [ Homo sapiens (human) ]

Gene ID: 196883, updated on 24-Nov-2020

Summary

Official Symbol
ADCY4provided by HGNC
Official Full Name
adenylate cyclase 4provided by HGNC
Primary source
HGNC:HGNC:235
See related
Ensembl:ENSG00000129467 MIM:600292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AC4
Summary
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Expression
Broad expression in placenta (RPKM 14.4), fat (RPKM 11.6) and 23 other tissues See more
Orthologs

Genomic context

See ADCY4 in Genome Data Viewer
Location:
14q12
Exon count:
26
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24318359..24335071, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24787555..24804277, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NOP9 nucleolar protein Neighboring gene cell death inducing DFFA like effector b Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor Neighboring gene receptor interacting serine/threonine kinase 3 Neighboring gene nuclear factor of activated T cells 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner PubMed
Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
Nef nef HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain PubMed
Tat tat HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RIPK3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adenylate cyclase type 4
Names
ATP pyrophosphate-lyase 4
adenylate cyclase type IV
adenylyl cyclase 4
NP_001185497.1
NP_001185521.1
NP_640340.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198568.2NP_001185497.1  adenylate cyclase type 4

    See identical proteins and their annotated locations for NP_001185497.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK122714, AL096870, BC117473
    Consensus CDS
    CCDS9627.1
    UniProtKB/Swiss-Prot
    Q8NFM4
    Related
    ENSP00000393177.2, ENST00000418030.6
    Conserved Domains (4) summary
    smart00044
    Location:219422
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8641063
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:479583
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:115246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  2. NM_001198592.2NP_001185521.1  adenylate cyclase type 4

    See identical proteins and their annotated locations for NP_001185521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK122714, BX248285
    Consensus CDS
    CCDS9627.1
    UniProtKB/Swiss-Prot
    Q8NFM4
    UniProtKB/TrEMBL
    Q86TZ7
    Related
    ENSP00000452250.2, ENST00000554068.6
    Conserved Domains (4) summary
    smart00044
    Location:219422
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8641063
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:479583
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:115246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  3. NM_139247.4NP_640340.2  adenylate cyclase type 4

    See identical proteins and their annotated locations for NP_640340.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK122714
    Consensus CDS
    CCDS9627.1
    UniProtKB/Swiss-Prot
    Q8NFM4
    Related
    ENSP00000312126.4, ENST00000310677.8
    Conserved Domains (4) summary
    smart00044
    Location:219422
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8641063
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:479583
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:115246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24318359..24335071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    619337..636049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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