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Rfc1 replication factor C (activator 1) 1 [ Mus musculus (house mouse) ]

Gene ID: 19687, updated on 16-Oct-2021

Summary

Official Symbol
Rfc1provided by MGI
Official Full Name
replication factor C (activator 1) 1provided by MGI
Primary source
MGI:MGI:97891
See related
Ensembl:ENSMUSG00000029191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Recc1; 140kDa; Alp145; RFC140
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.8), limb E14.5 (RPKM 8.3) and 28 other tissues See more
Orthologs
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Genomic context

See Rfc1 in Genome Data Viewer
Location:
5 C3.1; 5 33.61 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65419195..65495960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65261852..65338617, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (65653091..65726878, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene kelch-like 5 Neighboring gene predicted gene, 54287 Neighboring gene WD repeat domain 19 Neighboring gene klotho beta Neighboring gene ribosomal protein L9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC96526

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA clamp unloader activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA clamp unloader activity ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA clamp unloading ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA replication factor C complex ISO
Inferred from Sequence Orthology
more info
 
part_of Elg1 RFC-like complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
replication factor C subunit 1
Names
A1 140 kDa subunit
A1-P145
ISRE-binding protein
RF-C 140 kDa subunit
activator 1 140 kDa subunit
activator 1 large subunit
activator 1 subunit 1
differentiation-specific element-binding protein
replication factor C 1
replication factor C 140 kDa subunit
replication factor C large subunit
replication factor C, 140 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347357.1NP_001334286.1  replication factor C subunit 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138654
    Consensus CDS
    CCDS84885.1
    UniProtKB/TrEMBL
    Q5U4B1
    Related
    ENSMUSP00000144954.2, ENSMUST00000203471.3
  2. NM_001347358.1NP_001334287.1  replication factor C subunit 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138654
    Consensus CDS
    CCDS84884.1
    UniProtKB/TrEMBL
    A0A0N5E9G7
    Related
    ENSMUSP00000134444.5, ENSMUST00000172732.8
  3. NM_011258.2NP_035388.2  replication factor C subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_035388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    BC085174, BG695244, BY714128, X72711
    Consensus CDS
    CCDS39096.1
    UniProtKB/Swiss-Prot
    P35601
    UniProtKB/TrEMBL
    G3X8Z6
    Related
    ENSMUSP00000144980.2, ENSMUST00000204965.3
    Conserved Domains (4) summary
    smart00382
    Location:632762
    AAA; ATPases associated with a variety of cellular activities
    cd00027
    Location:406477
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00004
    Location:632760
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam08519
    Location:8991052
    RFC1; Replication factor RFC1 C terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    65419195..65495960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503801.5XP_006503864.1  replication factor C subunit 1 isoform X1

    Conserved Domains (5) summary
    PTZ00121
    Location:14372
    PTZ00121; MAEBL; Provisional
    COG5275
    Location:268498
    COG5275; BRCT domain type II [General function prediction only]
    PRK04195
    Location:568986
    PRK04195; replication factor C large subunit; Provisional
    cd17752
    Location:399477
    BRCT_RFC1; BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins
    pfam08519
    Location:8981051
    RFC1; Replication factor RFC1 C terminal domain
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