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Pitpnm2 phosphatidylinositol transfer protein, membrane-associated 2 [ Mus musculus (house mouse) ]

Gene ID: 19679, updated on 8-Jan-2023

Summary

Official Symbol
Pitpnm2provided by MGI
Official Full Name
phosphatidylinositol transfer protein, membrane-associated 2provided by MGI
Primary source
MGI:MGI:1336192
See related
Ensembl:ENSMUSG00000029406 AllianceGenome:MGI:1336192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NIR3; Rdgb2; RDGBA2; mKIAA1457
Summary
Predicted to enable several functions, including phospholipid binding activity; phospholipid transporter activity; and receptor tyrosine kinase binding activity. Predicted to be involved in phosphatidylinositol-mediated signaling. Predicted to be located in cytoskeleton and membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human PITPNM2 (phosphatidylinositol transfer protein membrane associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 44.3), adrenal adult (RPKM 32.8) and 25 other tissues See more
Orthologs
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Genomic context

See Pitpnm2 in Genome Data Viewer
Location:
5 F; 5 63.39 cM
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124256752..124387973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124118689..124249910, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 2 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 4 Neighboring gene predicted gene, 52788 Neighboring gene uncharacterized LOC115490137 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 2 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 1 Neighboring gene M-phase phosphoprotein 9 Neighboring gene mitochondrial translation release factor in rescue

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISA
Inferred from Sequence Alignment
more info
PubMed 
enables phospholipid transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
membrane-associated phosphatidylinositol transfer protein 2
Names
drosophila retinal degeneration B homolog 2
pyk2 N-terminal domain-interacting receptor 3
retinal degeneration B2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289472.1NP_001276401.1  membrane-associated phosphatidylinositol transfer protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001276401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AK129364, AW060604, BC070452
    Consensus CDS
    CCDS71669.1
    UniProtKB/Swiss-Prot
    Q6ZPQ6, Q9R1P5
    UniProtKB/TrEMBL
    Q6NS55
    Related
    ENSMUSP00000124111.2, ENSMUST00000161938.8
    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:10941225
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:9911140
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704948
    DDHD; DDHD domain
  2. NM_011256.3NP_035386.1  membrane-associated phosphatidylinositol transfer protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AF058693, AW060604, BC070452, BC082303
    Consensus CDS
    CCDS19674.1
    UniProtKB/Swiss-Prot
    Q6ZPQ6
    UniProtKB/TrEMBL
    Q6NS55
    Related
    ENSMUSP00000124740.2, ENSMUST00000162812.8
    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:10401171
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:9371086
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704894
    DDHD; DDHD domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124256752..124387973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254223.1XP_030110083.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9R1P5
    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:10941225
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:9911140
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704948
    DDHD; DDHD domain
  2. XM_030254224.1XP_030110084.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X3

    UniProtKB/TrEMBL
    E9PYJ7
    Related
    ENSMUSP00000124292.2, ENSMUST00000161273.8
    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:10901221
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:9871136
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704944
    DDHD; DDHD domain
  3. XM_006530214.2XP_006530277.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530277.1

    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:11441275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:10411190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704998
    DDHD; DDHD domain
  4. XM_006530215.5XP_006530278.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530278.1

    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:11441275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:10411190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704998
    DDHD; DDHD domain
  5. XM_006530217.4XP_006530280.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530280.1

    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:11441275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:10411190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704998
    DDHD; DDHD domain
  6. XM_030254225.1XP_030110085.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X4

    Conserved Domains (4) summary
    smart00775
    Location:10781209
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:9751124
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:638932
    DDHD; DDHD domain
    cl14643
    Location:1192
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  7. XM_030254226.2XP_030110086.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X5

    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:10401171
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:9371086
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704894
    DDHD; DDHD domain
  8. XM_036164922.1XP_036020815.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X3

    UniProtKB/TrEMBL
    E9PYJ7
    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:10901221
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:9871136
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704944
    DDHD; DDHD domain
  9. XM_006530216.5XP_006530279.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530279.1

    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:11441275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:10411190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704998
    DDHD; DDHD domain
  10. XM_030254227.2XP_030110087.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X5

    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:10401171
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:9371086
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704894
    DDHD; DDHD domain
  11. XM_006530218.5XP_006530281.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530281.1

    Conserved Domains (4) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:11441275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:10411190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704998
    DDHD; DDHD domain
  12. XM_036164923.1XP_036020816.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JFQ8
    Conserved Domains (1) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
  13. XM_036164925.1XP_036020818.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JFQ8
    Related
    ENSMUSP00000143269.2, ENSMUST00000159677.8
    Conserved Domains (1) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
  14. XM_036164924.1XP_036020817.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JFQ8
    Conserved Domains (1) summary
    cd08889
    Location:1258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)