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PAOX polyamine oxidase [ Homo sapiens (human) ]

Gene ID: 196743, updated on 5-Sep-2021

Summary

Official Symbol
PAOXprovided by HGNC
Official Full Name
polyamine oxidaseprovided by HGNC
Primary source
HGNC:HGNC:20837
See related
Ensembl:ENSG00000148832 MIM:615853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAO
Expression
Broad expression in testis (RPKM 17.7), spleen (RPKM 4.1) and 20 other tissues See more
Orthologs
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Genomic context

See PAOX in Genome Data Viewer
Location:
10q26.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (133379262..133391694)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135192766..135205198)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene fucose mutarotase Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene microRNA 3944 Neighboring gene mitochondrial ribosome associated GTPase 1 Neighboring gene shadow of prion protein Neighboring gene olfactory receptor family 6 subfamily L member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MTG1

Homology

Clone Names

  • MGC45464, DKFZp434J245

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Names
peroxisomal N1-acetyl-spermine/spermidine oxidase
polyamine oxidase (exo-N4-amino)
NP_690875.1
NP_997010.1
NP_997011.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152911.4NP_690875.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1

    See identical proteins and their annotated locations for NP_690875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF312698, BE646315
    Consensus CDS
    CCDS7683.1
    UniProtKB/Swiss-Prot
    Q6QHF9
    Related
    ENSP00000278060.5, ENST00000278060.10
    Conserved Domains (1) summary
    PLN02568
    Location:14497
    PLN02568; polyamine oxidase
  2. NM_207127.3NP_997010.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 2

    See identical proteins and their annotated locations for NP_997010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA280165, AF312698, AY541514, AY541519
    Consensus CDS
    CCDS7684.1
    UniProtKB/Swiss-Prot
    Q6QHF9
    Related
    ENSP00000435514.1, ENST00000480071.2
    Conserved Domains (2) summary
    PLN02568
    Location:14297
    PLN02568; polyamine oxidase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_207128.3NP_997011.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 3' coding region, resulting in a frameshift, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF312698, BE646315
    Consensus CDS
    CCDS7682.1
    UniProtKB/Swiss-Prot
    Q6QHF9
    Related
    ENSP00000349847.3, ENST00000357296.7
    Conserved Domains (2) summary
    PLN02568
    Location:14400
    PLN02568; polyamine oxidase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RNA

  1. NR_109763.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA280165, AF312698, AY541513, AY541519
  2. NR_109764.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes an alternate exon in the 5' coding region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA280165, AF312698, AY541518, AY541519
    Related
    ENST00000476834.6
  3. NR_109765.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA280165, AF312698, AY541517
    Related
    ENST00000483211.6
  4. NR_109766.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA280165, AF312698, AY541514, AY541519
    Related
    ENST00000529585.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    133379262..133391694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207125.1: Suppressed sequence

    Description
    NM_207125.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_207126.1: Suppressed sequence

    Description
    NM_207126.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_207129.1: Suppressed sequence

    Description
    NM_207129.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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