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VSTM4 V-set and transmembrane domain containing 4 [ Homo sapiens (human) ]

Gene ID: 196740, updated on 25-Nov-2021

Summary

Official Symbol
VSTM4provided by HGNC
Official Full Name
V-set and transmembrane domain containing 4provided by HGNC
Primary source
HGNC:HGNC:26470
See related
Ensembl:ENSG00000165633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf72
Expression
Broad expression in adrenal (RPKM 18.4), ovary (RPKM 14.7) and 19 other tissues See more
Orthologs
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Genomic context

See VSTM4 in Genome Data Viewer
Location:
10q11.23
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (49014236..49129118, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50222281..50323567, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene WDFY family member 4 Neighboring gene uncharacterized LOC105378298 Neighboring gene microRNA 4294 Neighboring gene FAM170B antisense RNA 1 Neighboring gene family with sequence similarity 170 member B Neighboring gene transmembrane protein 273

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31737, MGC44086

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in retina blood vessel maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in retina vasculature development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
V-set and transmembrane domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031746.5NP_001026916.2  V-set and transmembrane domain-containing protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026916.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC060234, AK056299, AK297931, AW058485, BC041414, HY112498
    Consensus CDS
    CCDS31198.1
    UniProtKB/Swiss-Prot
    Q8IW00
    Related
    ENSP00000331062.3, ENST00000332853.9
  2. NM_144984.4NP_659421.1  V-set and transmembrane domain-containing protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_659421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK056299, HY112498
    Consensus CDS
    CCDS7228.1
    UniProtKB/Swiss-Prot
    Q8IW00
    Related
    ENSP00000298454.3, ENST00000298454.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    49014236..49129118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015825.2XP_016871314.1  V-set and transmembrane domain-containing protein 4 isoform X1

  2. XM_017015827.2XP_016871316.1  V-set and transmembrane domain-containing protein 4 isoform X3

  3. XM_017015828.1XP_016871317.1  V-set and transmembrane domain-containing protein 4 isoform X4

  4. XM_017015826.1XP_016871315.1  V-set and transmembrane domain-containing protein 4 isoform X2

RNA

  1. XR_001747052.2 RNA Sequence

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