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Rce1 Ras converting CAAX endopeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 19671, updated on 12-May-2024

Summary

Official Symbol
Rce1provided by MGI
Official Full Name
Ras converting CAAX endopeptidase 1provided by MGI
Primary source
MGI:MGI:1336895
See related
Ensembl:ENSMUSG00000024889 AllianceGenome:MGI:1336895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D19Ertd98e; D19Ertd283e
Summary
Predicted to enable exopeptidase activity and metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing and protein prenylation. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 53.2), ovary adult (RPKM 49.6) and 28 other tissues See more
Orthologs
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Genomic context

See Rce1 in Genome Data Viewer
Location:
19 A; 19 4.07 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4672621..4675673, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4622593..4625645, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010003K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E778 Neighboring gene STARR-seq mESC enhancer starr_45350 Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene microRNA 6986 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene predicted gene 21992

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables exopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in CAAX-box protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein prenylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CAAX prenyl protease 2
Names
FACE-2
RCE1 homolog, prenyl protein peptidase
Ras and a-factor-converting enzyme 1 homolog
farnesylated proteins-converting enzyme 2
prenyl protein-specific endoprotease 2
NP_001355641.1
NP_001355642.1
NP_001355643.1
NP_001355644.1
NP_075620.1
XP_030106653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368712.1NP_001355641.1  CAAX prenyl protease 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC128739
    Conserved Domains (1) summary
    pfam02517
    Location:171216
    Abi; CAAX protease self-immunity
  2. NM_001368713.1NP_001355642.1  CAAX prenyl protease 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC128739
    Consensus CDS
    CCDS89304.1
    UniProtKB/TrEMBL
    A0A494B9U4
    Related
    ENSMUSP00000157811.2, ENSMUST00000237022.2
    Conserved Domains (1) summary
    pfam02517
    Location:67112
    Abi; CAAX protease self-immunity
  3. NM_001368714.1NP_001355643.1  CAAX prenyl protease 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform d.
    Source sequence(s)
    AC128739
    Consensus CDS
    CCDS89303.1
    UniProtKB/TrEMBL
    A0A286YD70, A0A494BAL8, Q99KQ3
    Conserved Domains (1) summary
    pfam02517
    Location:67162
    Abi; CAAX protease self-immunity
  4. NM_001368715.1NP_001355644.1  CAAX prenyl protease 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform d.
    Source sequence(s)
    AC128739
    Consensus CDS
    CCDS89303.1
    UniProtKB/TrEMBL
    A0A286YD70, A0A494BAL8, Q99KQ3
    Related
    ENSMUSP00000153695.2, ENSMUST00000224707.2
    Conserved Domains (1) summary
    pfam02517
    Location:67162
    Abi; CAAX protease self-immunity
  5. NM_023131.2NP_075620.1  CAAX prenyl protease 2 isoform b

    See identical proteins and their annotated locations for NP_075620.1

    Status: VALIDATED

    Source sequence(s)
    AC128739
    Consensus CDS
    CCDS29432.1
    UniProtKB/Swiss-Prot
    P57791, Q9CSF8, Q9EP68
    Related
    ENSMUSP00000025823.4, ENSMUST00000025823.6
    Conserved Domains (2) summary
    COG1266
    Location:169269
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam02517
    Location:164267
    Abi; CAAX protease self-immunity

RNA

  1. NR_160877.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739
  2. NR_160878.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739
  3. NR_160879.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739
  4. NR_160880.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739
  5. NR_160881.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739
  6. NR_160882.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739
  7. NR_160883.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739, BC048686
    Related
    ENSMUST00000225476.2
  8. NR_160884.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739
  9. NR_160885.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4672621..4675673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250793.2XP_030106653.1  CAAX prenyl protease 2 isoform X1

    UniProtKB/TrEMBL
    A0A494B9U4
    Conserved Domains (1) summary
    pfam02517
    Location:67112
    Abi; CAAX protease self-immunity